3 Results for "

Icotrokinra

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "Icotrokinra" in MCE Product Catalog:

Cat. No.: HY-P10587
CAS No.: 2763602-16-8
Synonyms: JNJ-77242113; JNJ-2113; PN-235
Research Areas:  

Inflammation/Immunology

Icotrokinra (JNJ-77242113) is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .
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Cat. No.: HY-P10587A
Synonyms: JNJ-77242113 acetate; JNJ-2113 acetate; PN-235 acetate
Research Areas:  

Inflammation/Immunology

Icotrokinra (JNJ-77242113) acetate is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra acetate inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra acetate exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra acetate can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .
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Cat. No.: HY-P10587B
Synonyms: JNJ-77242113 hydrochloride; JNJ-2113 hydrochloride; PN-235 hydrochloride
Research Areas:  

Inflammation/Immunology

Icotrokinra (JNJ-77242113) hydrochloride is an orally available, selective antagonist of the IL-23 receptor. Icotrokinra hydrochloride inhibits IL-23-induced STAT3 phosphorylation in peripheral blood mononuclear cells (IC50=5.6 pM) and inhibits IL-23-induced interferon IFN-γ production in NK cells with an IC50 of 18.4 pM. Icotrokinra hydrochloride exhibits anti-inflammatory activity in a rat TNBS-induced colitis model. Icotrokinra hydrochloride can be used in the study of psoriasis, psoriatic arthritis, and inflammatory bowel disease .
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