1 Result for "

KTN0073

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "KTN0073" in MCE Product Catalog:

KTN0073
KTN0073
0 Images
Cat. No.: HY-P992396

Target:  

c-Met/HGFR

Research Areas:  

Cancer

KTN0073 is a high-affinity MET receptor tyrosine kinase inhibitor. KTN0073 can be used in studies related to non-small cell lung cancer and human cancers driven by HGF, MET amplification, or exon 14 mutation. KTN0073 binds to the Sema/PSI domain to block the HGF-MET interaction, and induces ubiquitination and degradation of oncogenic MET receptors via an HGF-independent pathway, thereby inhibiting MET-dependent signal transduction. KTN0073 exhibits significant antitumor activity in vivo, and its tumor suppressive activity is superior to that of the IgG1 subtype when grafted to the IgG2 constant region .
loading...
    loading...
View All Sizes
Assay Types