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L032

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name
  • HY-L032V
    MCE Fragment Library
    		41,252 compounds
    A unique collection of 41,252 fragment compounds for high-throughput screening (HTS).
  • HY-L032
    Fragment Library
    		23,342 compounds

    Fragment-based drug discovery (FBDD) is well suited for discovering both drug leads and chemical probes of protein function; it can cover broad swaths of chemical space and allows the use of creative chemistry. Fragment-based drug discovery is well-established in industry and has resulted in a variety of drugs entering clinical trials, with two, vemurafenib and venetoclax, already approved. FBDD also has key attractions for academia. Notably, it is able to tackle difficult or novel targets for which no chemical matter may be found in existing HTS collections.

    MCE designs a unique collection of 23,342 fragment compounds, all of which obey a heuristic rule called the “Rule of Three (RO3) ”, in which molecular weight ≤300 Da, the number of hydrogen bond donors (H-donors) ≤3, the number of hydrogen bond acceptors (H-acceptors) is ≤3 and cLogP is ≤3. This library is an important source of lead-like drugs.

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