1 Result for "

MEDI579

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "MEDI579" in MCE Product Catalog:

Cat. No.: HY-P992410

Target:  

PAI-1 TGF-beta/Smad

Research Areas:  

Inflammation/Immunology

MEDI-579 is a fully human monoclonal antibody against PAI-1, with a KD value of 6 pM for human PAI-1 and 105 pM for rat PAI-1. MEDI-579 restores renal plasmin activity and inhibits PAI-1-mediated intracellular signal transduction. MEDI-579 reduces albuminuria, glomerulosclerosis severity, TGF-β1 expression level, and phosphorylated Smad2 level induced in diabetic mice. MEDI-579 decreases the levels of active PAI-1 in plasma and kidneys, and increases plasma plasmin level in a mouse model of lupus nephritis. MEDI-579 can be used in research related to diabetic nephropathy and lupus nephritis. The recommended isotype control is human IgG1 kappa (HY-P99001) .
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