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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
4 Results for "
MS 41
" in MedChemExpress (MCE) Product Catalog:
Products (4)
4 Results for "MS 41" in MCE Product Catalog:
Cat. No.: HY-169093
CAS No.: 2768610-97-3
Target:
Research Areas:
MS41 is a ENL PROTAC degrader with a DC50 of 3.50 nM. MS41 recruits the VHL E3 ubiquitin ligase, triggers ENL degradation via the ubiquitin-proteasome system, and simultaneously induces AF9 degradation. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation complexes, suppresses oncogene expression, and activates differentiation gene expression. MS41 inhibits leukemia cell growth and induces cell cycle arrest and apoptosis. MS41 inhibits leukemia progression in xenograft mouse models. MS41 can be used for research on mixed lineage leukemia-rearranged leukemia and nephroblastoma .
Cat. No.: HY-169094
CAS No.: 2768514-05-0
Research Areas:
PFI-6-COOH (Compound 18) is an eleven-nineteen leukemia (ENL) ligand, and can be used for synthesis of MS41 (HY-169093), an ENL PROTAC degrader .
Cat. No.: HY-169088
Research Areas:
VL285 Phenol-PEG2-Cl is the conjugate of E3 Ligase ligand and PROTAC Linker, whcich can be used to synthesize PROTACs, such as MS41 (HY-169086).
Cat. No.: HY-169095
CAS No.: 2458219-94-6
Research Areas:
(S,R,S)-AHPC-Me-CO-C9-NH2yes E3Ligase ligand and PROTAC LinkerThe conjugate can be used to synthesize PROTACMolecules, such as MS41 (HY-169093).
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
