11 Results for "

Ponatinib

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "Ponatinib" in MCE Product Catalog:

55
Ponatinib
Ponatinib
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55 Cited Publications
Cat. No.: HY-12047
CAS No.: 943319-70-8
Pureté:  99.67%
Synonyms: AP24534
Target:  

Bcr-Abl PDGFR VEGFR FGFR Src Autophagy

Domaines de recherche:  

Neurological Disease Inflammation/Immunology Cancer

Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .
55
Ponatinib hydrochloride
Ponatinib hydrochloride
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55 Cited Publications
Cat. No.: HY-108766
CAS No.: 1114544-31-8
Pureté:  99.76%
Synonyms: AP24534 hydrochloride
Target:  

Bcr-Abl FGFR PDGFR VEGFR Src Autophagy

Domaines de recherche:  

Infection Cancer

Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .
Ponatinib-d8
Ponatinib-d8
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Cat. No.: HY-12047S
CAS No.: 1562993-37-6
Pureté:  99.91%
Synonyms: AP24534-d8
Ponatinib-d8 (AP24534-d8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Ponatinib hydrochloride (Standard)
Ponatinib hydrochloride (Standard)
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Cat. No.: HY-108766R
CAS No.: 1114544-31-8
Synonyms: AP24534 hydrochloride (Standard)
Target:  

Bcr-Abl FGFR PDGFR VEGFR Src Autophagy Reference Standards

Domaines de recherche:  

Infection Cancer

Ponatinib (hydrochloride) (Standard) is the analytical standard of Ponatinib (hydrochloride). This product is intended for research and analytical applications. Ponatinib hydrochloride (AP24534 hydrochloride) is a hydrochloride of ponatinib. Ponatinib is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .
AP24600
AP24600
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Cat. No.: HY-W059917
CAS No.: 1300690-48-5
Target:  

Drug Metabolite

Domaines de recherche:  

Others

AP24600 is an inactive metabolite of Ponatinib .
Ponatinib (Standard)
Ponatinib (Standard)
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Cat. No.: HY-12047R
CAS No.: 943319-70-8
Synonyms: AP24534 (Standard)
Target:  

Reference Standards Bcr-Abl PDGFR VEGFR FGFR Src Autophagy

Domaines de recherche:  

Cancer

Ponatinib (Standard) is the analytical standard of Ponatinib. This product is intended for research and analytical applications. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively .
Ponatinib Acid
Ponatinib Acid
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Cat. No.: HY-135636
CAS No.: 2748500-17-4
Ponatinib Acid, an analogue of Ponatinib, is usually used as a labeled chemical or fluorescent probe. Ponatinib Acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
HSN748
HSN748
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Cat. No.: HY-171146
CAS No.: 2409925-53-5
Target:  

FLT3 Bcr-Abl RET PDGFR MNK

Domaines de recherche:  

Cancer

HSN748 is a Ponatinib (HY-12047) analogue and a multikinase inhibitor. HSN748 has inhibitory activity on FLT3, ABL1, RET, PDGFRα/β, MNK1, MNK2 and other kinases. HSN748 can inhibit the growth of chronic myeloid leukemia and acute myeloid leukemia cell lines and can be used in the study of leukemia .
FGFR4-IN-22
FGFR4-IN-22
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Cat. No.: HY-170690
CAS No.: 2922812-74-4
Target:  

FGFR

Domaines de recherche:  

Cancer

FGFR4-IN-22 (compound 10f) is a potent inhibitor of FGFR4, with the IC50 of 5.4 nM. FGFR4-IN-22 serve as a potential lead compound targeting FGFR4 for anti-HCC agent development .
VEGFR-IN-5
VEGFR-IN-5
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Cat. No.: HY-163881
Target:  

VEGFR

Domaines de recherche:  

Cancer

VEGFR-IN-5 (compound 9k) is a potent inhibitor of VEGFR2, with the IC50 of 8.4 nM and an acceptable oral bioavailability. VEGFR-IN-5 inhibits migration and invasion of human umbilical vein endothelial cells (HUVEC) cells and induces apoptosis .
P19P
P19P
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Cat. No.: HY-180977
CAS No.: 2512843-74-0
Target:  

PROTACs Bcr-Abl

Domaines de recherche:  

Cancer

P19P is a BCR-ABL PROTAC degrader based on Ponatinib (HY-12047), with a DC50 value of approximately 20 nM for the wild-type BCR-ABL protein. P19P can effectively degrade various drug-resistant mutants such as T315I, E255K, H396R, and V468F, and exhibits potent anti-proliferative activity in BaF3-BCR-ABL (T315I) cells. P19P maintains strong inhibitory activity against ABL (T315I), with a IC50 of 13.1 nM. P19P does not inhibit the formation of vascular lumens in HUVEC. P19P can be used for research on chronic myeloid leukemia and acute lymphoblastic leukemia .
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