1. Protein Tyrosine Kinase/RTK Autophagy
  2. Bcr-Abl PDGFR VEGFR FGFR Src Autophagy
  3. Ponatinib-d8

Ponatinib-d8  (Synonyms: AP24534-d8)

Cat. No.: HY-12047S Purity: 99.91%
COA Handling Instructions

Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

Ponatinib-d<sub>8</sub> Chemical Structure

Ponatinib-d8 Chemical Structure

CAS No. : 1562993-37-6

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Based on 1 publication(s) in Google Scholar

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  • Biological Activity

  • Purity & Documentation

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Description

Ponatinib-d8 is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

IC50 & Target[1]

c-Kit

12.5 nM (IC50)

VEGFR2

1.5 nM (IC50)

FGFR1

2.2 nM (IC50)

PDGFRα

1.1 nM (IC50)

Molecular Weight

540.61

Formula

C29H19D8F3N6O

CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Ponatinib-d8 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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