1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. Bcr-Abl
    PDGFR
    VEGFR
    FGFR
    Src
    Autophagy
  3. Ponatinib-d8

Ponatinib-d8 (Synonyms: AP24534-d8)

Cat. No.: HY-12047S Purity: 98.44%
Handling Instructions

Ponatinib D8 (AP24534 D8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

Ponatinib-d8 Chemical Structure

Ponatinib-d8 Chemical Structure

CAS No. : 1562993-37-6

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1 mg USD 1055 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Ponatinib D8 (AP24534 D8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

IC50 & Target[1]

c-Kit

12.5 nM (IC50)

VEGFR2

1.5 nM (IC50)

FGFR1

2.2 nM (IC50)

PDGFRα

1.1 nM (IC50)

Molecular Weight

540.61

Formula

C29H19D8F3N6O

CAS No.
SMILES

O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
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