Ponatinib-d8
Based on 1 Customer Validation
Ponatinib-d8 (AP24534-d8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.
Para uso exclusivo en investigación. No vendemos a pacientes.
- Pureza : 99.16%
- No. CAS: 1562993-37-6
- Fòrmula: C29H19D8F3N6O
- Peso molecular:540.61
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Almacenamiento:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Actividad biológica
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Chemical Information
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Solvente y solubilidad
- Pureza y Documentación
- Referencias
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Help & FAQs
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Actividad biológica
Descripciòn
IC50 & Target
[1]|
c-Kit 12.5 nM (IC50) |
VEGFR2 1.5 nM (IC50) |
FGFR1 2.2 nM (IC50) |
PDGFRα 1.1 nM (IC50) |
In Vitro
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Aplicación
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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No. CAS 1562993-37-6
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Unlabeled CAS 943319-70-8
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Appearance Solid
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Peso molecular 540.61
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Fòrmula C29H19D8F3N6O
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Color White to light yellow
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SMILES
O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3
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Synonyms
AP24534-d8
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvente y solubilidad
In Vitro:
1 M HCl : 50 mg/mL (92.49 mM; ultrasonic and adjust pH to 1 with HCl)
DMSO : 25 mg/mL (46.24 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureza y Documentación
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Ficha de datos (276 KB)
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SDS (645 KB)
- English - EN (645 KB)
- Français - FR (645 KB)
- Deutsch - DE (645 KB)
- Norwegian - NO (645 KB)
- Español - ES (645 KB)
- Swedish - SV (645 KB)
- Italian - IT (645 KB)
- Korean - KR (645 KB)
- Portuguese - PT (645 KB)
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Instrucciones de manejo (2659 KB)
Referencias
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO / 1 M HCl | 1 mM | 1.8498 mL | 9.2488 mL | 18.4976 mL | 46.2441 mL |
| 5 mM | 0.3700 mL | 1.8498 mL | 3.6995 mL | 9.2488 mL | |
| 10 mM | 0.1850 mL | 0.9249 mL | 1.8498 mL | 4.6244 mL | |
| 15 mM | 0.1233 mL | 0.6166 mL | 1.2332 mL | 3.0829 mL | |
| 20 mM | 0.0925 mL | 0.4624 mL | 0.9249 mL | 2.3122 mL | |
| 25 mM | 0.0740 mL | 0.3700 mL | 0.7399 mL | 1.8498 mL | |
| 30 mM | 0.0617 mL | 0.3083 mL | 0.6166 mL | 1.5415 mL | |
| 40 mM | 0.0462 mL | 0.2312 mL | 0.4624 mL | 1.1561 mL | |
| 1 M HCl | 50 mM | 0.0370 mL | 0.1850 mL | 0.3700 mL | 0.9249 mL |
| 60 mM | 0.0308 mL | 0.1541 mL | 0.3083 mL | 0.7707 mL | |
| 80 mM | 0.0231 mL | 0.1156 mL | 0.2312 mL | 0.5781 mL |
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