1. Protein Tyrosine Kinase/RTK
    Autophagy
  2. Bcr-Abl
    PDGFR
    VEGFR
    FGFR
    Src
    Autophagy
  3. Ponatinib D8

Ponatinib D8 (Synonyms: AP24534 D8)

Cat. No.: HY-12047S
Handling Instructions

Ponatinib D8 (AP24534 D8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

For research use only. We do not sell to patients.

Ponatinib D8 Chemical Structure

Ponatinib D8 Chemical Structure

CAS No. : 1562993-37-6

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Description

Ponatinib D8 (AP24534 D8) is a deuterium labeled Ponatinib. Ponatinib (AP24534) is an orally active multi-targeted kinase inhibitor with IC50s of 0.37 nM, 1.1 nM, 1.5 nM, 2.2 nM, and 5.4 nM for Abl, PDGFRα, VEGFR2, FGFR1, and Src, respectively.

IC50 & Target[1]

c-Kit

12.5 nM (IC50)

VEGFR2

1.5 nM (IC50)

FGFR1

2.2 nM (IC50)

PDGFRα

1.1 nM (IC50)

Molecular Weight

540.61

Formula

C₂₉H₁₉D₈F₃N₆O

CAS No.

1562993-37-6

SMILES

O=C(NC1=CC=C(CN2C([2H])([2H])C([2H])([2H])N(C)C([2H])([2H])C2([2H])[2H])C(C(F)(F)F)=C1)C3=CC=C(C)C(C#CC4=CN=C5C=CC=NN54)=C3

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Room temperature in continental US; may vary elsewhere.

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Ponatinib D8AP24534 D8Ponatinib D 8Ponatinib D-8Bcr-AblPDGFRVEGFRFGFRSrcAutophagyPlatelet-derived growth factor receptorVascular endothelial growth factor receptorFibroblast growth factor receptororallyactivemulti-targetedkinaseAblPDGFRαVEGFR2FGFR1Inhibitorinhibitorinhibit

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