1 Result for "

SCID SHO mice

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SCID SHO mice" in MCE Product Catalog:

Referencia número: HY-184178A
Target:  

Apoptosis

Áreas de investigación:  

Cancer

HF-125 is an orally active, highly selective small-molecule inhibitor of Tribbles 2 (TRIB2). HF-125 promotes the destabilization and degradation of TRIB2 protein via the proteasome pathway. HF-125 downregulates neuroendocrine markers, induces cell cycle arrest and apoptosis, inhibits tumor cell colony formation and invasion, and reverses tumor cell resistance to Enzalutamide (HY-70002). HF-125 significantly inhibits tumor growth in SCID mouse xenograft models, and exerts synergistic inhibitory effects when combined with Enzalutamide. HF-125 can be used in research related to prostate cancer .
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