1 Result for "

SRI31142

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SRI31142" in MCE Product Catalog:

Cat. No.: HY-117902
CAS No.: 1940118-04-6
Purity:  99.89%
Target:  

Dopamine Transporter

Research Areas:  

Neurological Disease

SRI-31142 is a putative, brain-penetrant allosteric inhibitor of the dopamine transporter (DAT). In behavioral studies using intracranial self-stimulation (ICSS), SRI-31142 did not produce the abuse-related effects seen with cocaine and GBR-12935, but instead reduced ICSS responses and dopamine levels in the nucleus accumbens (NAc) at effective doses. SRI-31142 also blocked cocaine-induced increases in ICSS and NAc dopamine .
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