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STING-IN-15

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-173425
    STING-IN-15

    		STING IFNAR TNF Receptor Interleukin Related Inflammation/Immunology
    STING-IN-15 is an orally active STING inhibitor, with an IC50 of 116 nM against h-STING and an IC50 of 96.3 nM against m-STING. STING-IN-15 inhibits the STING signaling pathway in cells, reduces the secretion of IFN-β and IP-10, downregulates the expression of ISG15, ISG56 and TNF-α, and suppresses the phosphorylation of TBK1/IRF3. STING-IN-15 alleviates systemic and renal inflammation induced by STING agonists in mice, reduces tissue damage and the expression of interferon pathway genes, and inhibits spontaneous tissue inflammation in mice. STING-IN-15 can be used for the research of acute kidney injury and autoimmune/inflammatory diseases .
    STING-IN-15
  • HY-122568
    STING agonist-15

    		STING Inflammation/Immunology Cancer
    STING agonist-15 is a STING agonist. STING agonist-15 can be used for research on cancer and autoimmune diseases .
    STING agonist-15

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