1 Result for "

TRX518

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "TRX518" in MCE Product Catalog:

  • Targets Recommended:
Cat. No.: HY-P991180

Target:  

TNF Receptor

Research Areas:  

Cancer

TRX-518 is a humanized agylcosyl IgG1 anti-GITR mAb, , and is a GITR agonist. TRX-518 binds to the extracellular domain of human GITR, abrogates Treg-mediated suppression. TRX-518 increases effector T cell activation and pro-inflammatory cytokine production, reduces circulating and intratumor Treg frequencies. TRX-518 destabilizes Treg phenotype via Foxp3 downregulation and T-bet upregulation. TRX-518 can be used for the research of solid tumors[1][2][3].
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