2 Results for "

Zimberelimab

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "Zimberelimab" in MCE Product Catalog:

Cat. No.: HY-P99109
CAS No.: 2259860-24-5
Synonyms: GLS-010; AB-122; WBP-3055

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Zimberelimab (GLS-010) is a fully human IgG4 anti-PD-1 monoclonal antibody with an EC50 of 210 pM for human PD-1. Zimberelimab effectively blocks the binding of PD-L1 and PD-L2 to cell-surface PD-1 in CHO-S cells, with IC50 values of 580 pM and 670 pM, respectively. Zimberelimab shows antitumor activities, and can be used for various cancers research, including cervical cancer, non-small cell lung cancer and classical Hodgkin’s lymphoma .
loading...
    loading...
Cat. No.: HY-159644
CAS No.: 2709069-30-5
Synonyms: AB521
Research Areas:  

Cancer

Casdatifan (AB521) is an orally active and selective allosteric small-molecule inhibitor of hypoxia-inducible factor 2α (HIF-2α). Casdatifan inhibits pro-tumor gene transcription by blocking the heterodimerization of HIF-2α with ARNT, and significantly suppresses tumor growth in clear cell renal cell carcinoma (ccRCC) models either as a monotherapy or in combination with agents such as Zimberelimab (HY-P99109). Casdatifan is applicable for the research of ccRCC .
loading...
    loading...