Hpn - hepsin Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29135

Summary

Predicted to enable serine-type endopeptidase activity. Predicted to be involved in several processes, including cochlea morphogenesis; positive regulation of nitrogen compound metabolic process; and regulation of epithelial cell proliferation. Predicted to act upstream of or within several processes, including Cholesterol homeostasis; negative regulation of Alkaline Phosphatase activity; and sensory perception of sound. Predicted to be located in several cellular components, including cell surface; endoplasmic reticulum membrane; and neuronal cell body. Predicted to be integral component of plasma membrane. Predicted to colocalize with nuclear membrane. Orthologous to human HPN (hepsin). [provided by Alliance of Genome Resources, Apr 2022]

Hpn Products (1)

mRNA Protein Name
NM_017112.1 NP_058808.1 serine protease hepsin precursor
Protein Preferred Names Protein Names

serine protease hepsin

  • hepsin (transmembrane protease, serine 1)

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-B2087 Glycerol phenylbutyrate 99.81% Yes

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P990920 Gocatamig Inhibitor ≥99.0% Phase 2
HY-P991088 HPN536 Inhibitor 99.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06342 HPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18736 Hpn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25223 Hpn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990939 Podentamig Inhibitor / Unkown
HY-P992370 HPN601 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Hpn NCBI NCBI:3249
Mus musculus Hpn NCBI NCBI:15451