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HPN536

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Based on 1 Customer Validation

HPN536 is a trispecific, T-cell-activating protein-based construct, which binds to mesothelin-expressing tumor cells, CD3ε on T cells, and to serum albumin. HPN536 specifically redirects T cells for potent redirected lysis of mesothelin-expressing cancer cells with concomitant T-cell activation.

For research use only. We do not sell to patients.

  • Purity: 99.00%
  • Molecular Weight:52.90 kDa
  • Storage:

    Please store the product under the recommended conditions in the Certificate of Analysis.

  • Experimental Validation Results for HPN536
  • Experimental Validation Results for HPN536
  • Experimental Validation Results for HPN536
  • Experimental Validation Results for HPN536
  • HPN536 Chemical Structure
    HPN536 Chemical Structure
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To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

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HPN536 Product Recommendations:

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
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Assay Types
  • 1/16

    TriTAC: VHH-VHH-scFV

  • 1/16

    Loaded HPN536 on SA biosensor, can bind Mesothelin Protein, Human (303a.a, HEK293, His, HY-P70148) with an affinity constant of 4.442E-10 M as determined in BLI assay.

  • 1/16

    Flow Cytometry analysis of Hela cells labelling Mesothelin (red) with HPN536 (anti-Mesothelin) (HY-P991088). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).

  • 1/16

    Flow Cytometry analysis of Jurkat cells labelling CD3E (red) with HPN536 (anti-CD3E) (HY-P991088). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).

  • HPN536 Chemical Structure
    1/16
  • HPN536
  • Loaded HPN536 on SA biosensor, can bind Mesothelin Protein, Human (303a.a, HEK293, His, HY-P70148) with an affinity constant of 4.442E-10 M as determined in BLI assay.
  • Flow Cytometry analysis of Hela cells labelling Mesothelin (red) with HPN536 (anti-Mesothelin) (HY-P991088). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).
  • Flow Cytometry analysis of Jurkat cells labelling CD3E (red) with HPN536 (anti-CD3E) (HY-P991088). Cells were stained with the primary antibody at 1/200 dilution for an hour at 4℃. Goat Anti-Human IgG H&L (AF488) (HY-P83776) was used as the secondary antibody at 1/1,000 dilution for 30 minutes at 4℃. Cells without incubation with primary antibody were used as the unlabeled control (black).
  • TriTAC: VHH-VHH-scFV