HPN - hepsin Gene

Also Known as TMPRSS1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3249

About HPN

Cytogenetic location: 19q13.11 Genomic coordinates (GRCh38): 19:35,040,506-35,066,573 (from NCBI)

This gene has 11 transcripts (splice variants), 194 orthologues and 17 paralogues. Biased expression in liver (RPKM 53.7), kidney (RPKM 49.5) and 5 other tissues.

Summary

This gene encodes a type II transmembrane serine protease that may be involved in diverse cellular functions, including blood coagulation and the maintenance of cell morphology. Expression of the encoded protein is associated with the growth and progression of cancers, particularly prostate Cancer. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

HPN Products (4)

mRNA Protein Name
NM_001375441.3 NP_001362370.1 serine protease hepsin precursor
NM_001384133.1 NP_001371062.1 serine protease hepsin precursor
NM_002151.5 NP_002142.1 serine protease hepsin precursor
NM_182983.5 NP_892028.1 serine protease hepsin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables peptidase activity IDA
IDA: Inferred from direct assay
16908524 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15614436 GOA
enables serine-type endopeptidase activity IDA
IDA: Inferred from direct assay
16908524 GOA
enables serine-type peptidase activity IDA
IDA: Inferred from direct assay
19911255 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in basement membrane disassembly IDA
IDA: Inferred from direct assay
16908524 GOA
involved in negative regulation of apoptotic process IDA
IDA: Inferred from direct assay
15614436 GOA
involved in negative regulation of epithelial cell proliferation IDA
IDA: Inferred from direct assay
19843851 GOA
involved in negative regulation of epithelial to mesenchymal transition IDA
IDA: Inferred from direct assay
19843851 GOA
involved in positive regulation by host of viral transcription IDA
IDA: Inferred from direct assay
15614436 GOA
involved in positive regulation of cell growth IMP
IMP: Inferred from mutant phenotype
8346233 GOA
involved in positive regulation of hepatocyte proliferation IDA
IDA: Inferred from direct assay
15614436 GOA
involved in positive regulation of plasminogen activation IDA
IDA: Inferred from direct assay
16908524 GOA
involved in proteolysis IDA
IDA: Inferred from direct assay
16908524 GOA
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
8346233 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cell surface IDA
IDA: Inferred from direct assay
8346233 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
17918732 GOA
located in membrane IDA
IDA: Inferred from direct assay
19843851 GOA
colocalizes with nuclear membrane IDA
IDA: Inferred from direct assay
15614436 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
1885621 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HPN Protein Structure

Hepsin-SRCR

Hepsin-SRCR: Hepsin, SRCR (50 - 159)

Trypsin

Trypsin: Trypsin (163 - 400)

  • 0
  • 100
  • 200
  • 300
  • 417 a.a.
Protein Preferred Names Protein Names

serine protease hepsin

  • testicular tissue protein Li 85

HPN Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
HPN P05981 SFTPC Homo sapiens P11686
Validated Y2H
32296183
Intra
HPN P05981 BNIP3 Homo sapiens Q12983
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant HPN Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P77693 TMPRSS1/HPN Protein, Human (HEK293, His) P05981 (R45-L417) ≥ 95%, as determined by Bis-Tris PAGE.

Related Diseases

Diseases Alias
Prostate Cancer

  • Prostate Carcinoma

  • Prostate Cancer, Familial

  • Prostate Neoplasm

  • Prostate Cancer, Somatic

  • Prostate Cancer, Susceptibility To

  • Prostatic Cancer

  • Prostatic Neoplasms

  • Hereditary Prostate Cancer

  • Prostatic Neoplasm

  • Cancer Of Prostate

  • Carcinoma Of Prostate

  • Familial Prostate Cancer

  • Familial Prostate Carcinoma

  • Malignant Tumor Of Prostate

  • Malignant Neoplasm Of Prostate

  • Prostate Cancer, Familial, Susceptibility To

  • Malignant Tumor Of The Prostate

  • Ngp - New Growth Of Prostate

  • Tumor Of The Prostate

  • Prostate Cancer, Hereditary

  • Cancer Of The Prostate

  • Malignant Neoplasm Of The Prostate

  • Prostatic Carcinoma

  • PC

  • Prca

  • Cancer, Prostate

  • Malignant Prostatic Tumour

  • Malignant Tumour Of Prostate

  • Primary Prostate Cancer

  • Primary Malignant Neoplasm Of Prostate

  • Prostate Gland Cancer
Prostatic Hyperplasia, Benign

  • Benign Prostatic Hyperplasia

  • BPH

  • Prostatic Hyperplasia
Deafness, Autosomal Recessive 39

  • DFNB39

  • Autosomal Recessive Nonsyndromic Deafness 39

  • Autosomal Recessive Deafness 39

  • Deafness, Autosomal Recessive, 39

  • Congenital Neurosensory Deafness Autosomal Recessive 39

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 39

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 39

  • Deafness, Autosomal Recessive, Type 39
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Rare Diseases
HY-B2087 Glycerol phenylbutyrate 99.81% Yes

Clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-135366 HPN-01 Inhibitor 98.61% Phase 1
Inhibitory Antibodies (2)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P990920 Gocatamig Inhibitor ≥99.0% Phase 2
HY-P991088 HPN536 Inhibitor 99.00% Phase 1

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06342 HPN Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18736 Hpn Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25223 Hpn Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (2)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-P990939 Podentamig Inhibitor / Unkown
HY-P992370 HPN601 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus HPN VGNC VGNC:67639
Bos taurus HPN VGNC VGNC:29942
Mus musculus HPN MGD MGI:1196620
Canis familiaris HPN VGNC VGNC:41772
Rattus norvegicus HPN RGD RGD:61982
Macaca mulatta HPN VGNC VGNC:73513
Others HPN NCBI