Hpn - hepsin Gene

Also Known as Hlb320

Species: Mus musculus

Gene Type: protein coding

Gene ID: 15451

Summary

This gene encodes a type II transmembrane serine protease that may function in diverse processes, including regulation of cell growth. Deficiency in this gene results in hearing loss. The protein is cleaved into a catalytic serine protease chain and a non-catalytic scavenger receptor cysteine-rich chain, which associate via a single disulfide bond. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2013]

Hpn Products (3)

mRNA	Protein	Name
NM_001110252.2	NP_001103722.1	serine protease hepsin isoform 1 precursor
NM_001276269.1	NP_001263198.1	serine protease hepsin isoform 3 precursor
NM_008281.4	NP_032307.2	serine protease hepsin isoform 2 precursor

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within cholesterol homeostasis	IMP IMP: Inferred from mutant phenotype	22912808	MGI
involved in cochlea morphogenesis	IMP IMP: Inferred from mutant phenotype	20683358	MGI
involved in detection of mechanical stimulus involved in sensory perception of sound	IMP IMP: Inferred from mutant phenotype	17620368	MGI
involved in epithelium development	IEP IEP: Inferred from expression pattern	8346233	MGI
acts upstream of or within negative regulation of alkaline phosphatase activity	IMP IMP: Inferred from mutant phenotype	22912808	MGI
involved in pilomotor reflex	IMP IMP: Inferred from mutant phenotype	17620368	MGI
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	17620368	MGI
involved in positive regulation of thyroid hormone generation	IMP IMP: Inferred from mutant phenotype	17620368	MGI
involved in potassium ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	17620368	MGI
involved in response to thyroid hormone	IMP IMP: Inferred from mutant phenotype	20683358	MGI
acts upstream of or within sensory perception of sound	IMP IMP: Inferred from mutant phenotype	22912808	MGI

Cellular Component GO Annotation	Evidence	References	Source
located in cell-cell junction	IMP IMP: Inferred from mutant phenotype	17620368	MGI
located in neuronal cell body	IDA IDA: Inferred from direct assay	17918732	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	12744720	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
serine protease hepsin

Recombinant Hpn Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77961	Hepsin/HPN Protein, Mouse (HEK293, His)	O35453 (T60-P436)	≥ 95%, as determined by Bis-Tris PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B2087	Glycerol phenylbutyrate		99.81%	Yes

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-135366	HPN-01	Inhibitor	98.61%	Phase 1

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P990920	Gocatamig	Inhibitor	≥99.0%	Phase 2
HY-P991088	HPN536	Inhibitor	99.00%	Phase 1

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06342	HPN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18736	Hpn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25223	Hpn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P990939	Podentamig	Inhibitor	/	Unkown
HY-P992370	HPN601	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hpn	NCBI	NCBI:3249