HNF4G - hepatocyte nuclear factor 4 gamma Gene

Also Known as NR2A2; NR2A3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3174

About HNF4G

Cytogenetic location: 8q21.13 Genomic coordinates (GRCh38): 8:75,407,649-75,566,834 (from NCBI)

This gene has 5 transcripts (splice variants), 240 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 55.0), duodenum (RPKM 46.4) and 5 other tissues.

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in several cellular components, including intercellular bridge; mitotic spindle; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

HNF4G Products (2)

mRNA Protein Name
NM_001330561.2 NP_001317490.1 hepatocyte nuclear factor 4-gamma isoform 2
NM_004133.5 NP_004124.5 hepatocyte nuclear factor 4-gamma isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: Inferred from direct assay
23896584 GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: Inferred from direct assay
12220531 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
23896584 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HNF4G Protein Structure

zf-C4

zf-C4: Zinc finger, C4 type (two domains) (11 - 79)

Hormone_recep

Hormone_recep: Ligand-binding domain of nuclear hormone receptor (124 - 312)

  • 0
  • 100
  • 200
  • 300
  • 408 a.a.
Protein Preferred Names Protein Names

hepatocyte nuclear factor 4-gamma

  • HNF-4-gamma

Related Diseases

Diseases Alias
Maturity-Onset Diabetes Of The Young, Type 1

  • Maturity-Onset Diabetes Of The Young Type 1

  • MODY1

  • Mild Juvenile Diabetes Mellitus

  • Mody, Type I

  • Diabetes Mellitus Type 2

  • Mody Type 1

  • Mody, Type 1

  • Maturity-Onset Diabetes Of The Young 1

  • Mody-1

  • Diabetes Of The Young, Maturity-Onset, Type 1
Maturity-Onset Diabetes Of The Young

  • MODY

  • Maturity Onset Diabetes Mellitus In Young

  • Mason-Type Diabetes

  • Mason Type Diabetes

  • Maturity Onset Diabetes Of The Young

  • Mody Syndrome

  • Diabetes Of The Young, Maturity-Onset
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS06258 HNF4G Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21595 Hnf4g Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28113 Hnf4g Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus HNF4G VGNC VGNC:29892
Mus musculus HNF4G MGD MGI:1353604
Rattus norvegicus HNF4G RGD RGD:1310102
Macaca mulatta HNF4G VGNC VGNC:73493
Felis catus HNF4G VGNC VGNC:67604
Canis familiaris HNF4G VGNC VGNC:41726
Others HNF4G NCBI