RNH1 - ribonuclease/angiogenin inhibitor 1 Gene

Also Known as RAI; RNH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6050

About RNH1

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:494,515-507,242 (from NCBI)

This gene has 24 transcripts (splice variants), 1 gene allele, 126 orthologues and 4 paralogues. Ubiquitous expression in skin (RPKM 36.6), lung (RPKM 36.0) and 25 other tissues.

Summary

Placental ribonuclease inhibitor (PRI) is a member of a family of proteinaceous cytoplasmic RNase inhibitors that occur in many tissues and bind to both intracellular and extracellular RNases (summarized by Lee et al., 1988 [PubMed 3219362]). In addition to control of intracellular RNases, the inhibitor may have a role in the regulation of angiogenin (MIM 105850). Ribonuclease inhibitor, of 50,000 Da, binds to ribonucleases and holds them in a latent form. Since neutral and alkaline ribonucleases probably play a critical role in the turnover of RNA in eukaryotic cells, RNH may be essential for control of mRNA turnover; the interaction of eukaryotic cells with ribonuclease may be reversible in vivo.[supplied by OMIM, Jul 2010]

RNH1 Products (8)

mRNA Protein Name
NM_002939.4 NP_002930.2 ribonuclease inhibitor
NM_203383.2 NP_976317.1 ribonuclease inhibitor
NM_203384.2 NP_976318.1 ribonuclease inhibitor
NM_203385.2 NP_976319.1 ribonuclease inhibitor
NM_203386.3 NP_976320.1 ribonuclease inhibitor
NM_203387.3 NP_976321.1 ribonuclease inhibitor
NM_203388.3 NP_976322.1 ribonuclease inhibitor
NM_203389.3 NP_976323.1 ribonuclease inhibitor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
2742853 GOA
enables ribonuclease inhibitor activity IDA
IDA: Inferred from direct assay
3219362 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of angiogenesis IDA
IDA: Inferred from direct assay
3470787 GOA
Cellular Component GO Annotation Evidence References Source
part of angiogenin-PRI complex IPI
IPI: Inferred from physical interaction
3470787 GOA
is active in cytoplasm IDA
IDA: Inferred from direct assay
23843625 GOA
is active in nucleus IDA
IDA: Inferred from direct assay
23843625 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNH1 Protein Structure

LRR_6

LRR_6: Leucine Rich repeat (112 - 135)

LRR_6

LRR_6: Leucine Rich repeat (228 - 248)

LRR_6

LRR_6: Leucine Rich repeat (285 - 306)

LRR_6

LRR_6: Leucine Rich repeat (342 - 363)

LRR_6

LRR_6: Leucine Rich repeat (397 - 416)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 461 a.a.
Protein Preferred Names Protein Names

ribonuclease inhibitor

  • placental RNase inhibitor

RNH1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNH1 P13489 RNASE1 Homo sapiens P07998
X-Ray Diffraction
17350650
Intra
RNH1 P13489 ANG Homo sapiens P03950
Anti Tag CoIP
33961781
Intra
RNH1 P13489 ANG Homo sapiens P03950
Fluorescence Spectr
10413501
Intra
RNH1 P13489 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
RNH1 P13489 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
RNH1 P13489 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
RNH1 P13489 SDCBP Homo sapiens O00560
Y2H Prey Pooling
32296183
Intra
RNH1 P13489 SDCBP Homo sapiens O00560
Y2H Array
32296183
Intra
RNH1 P13489 SDCBP Homo sapiens O00560
Y2H Array
25416956
Cross
RNH1 P13489 RNASE1 Bos taurus P61823
Ribonuclease Assay
10413501
Cross
RNH1 P13489 RNASE1 Bos taurus P61823
Affinity Techniques
10413501
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Lung Cancer

  • Lung Carcinoma

  • Non-Small Cell Lung Carcinoma

  • Lung Cancer, Susceptibility To

  • Lung Cancer, Protection Against

  • Adenocarcinoma Of Lung, Somatic

  • Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer

  • Lung Neoplasm

  • Carcinoma Of Lung

  • Lung Non-Small Cell Carcinoma

  • Non-Small Cell Lung Cancer

  • Nsclc

  • Lung Neoplasms

  • Malignant Neoplasm Of Lung

  • Alveolar Cell Carcinoma

  • Nonsmall Cell Lung Cancer, Somatic

  • Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

  • Nonsmall Cell Lung Cancer, Susceptibility To

  • Lung Cancer, Somatic

  • Lung Cancer, Resistance To

  • Cancer Of Lung

  • Cancer Of Bronchus

  • Cancer Of The Lung

  • Lung Malignancies

  • Lung Malignant Tumors

  • Malignant Lung Tumor

  • Malignant Tumor Of Lung

  • Pulmonary Cancer

  • Pulmonary Carcinoma

  • Pulmonary Neoplasms

  • Respiratory Carcinoma

  • LNCR

  • Adenocarcinoma Of Lung

  • Neoplasm Of Lung

  • Cancer Lung

  • Carcinoma Non-Small Cell Lung

  • Carcinoma, Non-Small-Cell Lung

  • Lung Cancers

  • Lung Carcinomas

  • Cancer, Lung

  • Cancer, Lung, Non-Small Cell

  • Primary Malignant Neoplasm Of Lung

  • Bronchioloalveolar Adenocarcinoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS12100 RNH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12024 RNASEH1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus RNH1 VGNC VGNC:64709
Mus musculus RNH1 MGD MGI:1195456
Bos taurus RNH1 VGNC VGNC:106900
Canis familiaris RNH1 VGNC VGNC:45680
Rattus norvegicus RNH1 RGD RGD:621398
Others RNH1 NCBI