RORA - RAR related orphan receptor A Gene

Also Known as ROR1; ROR2; ROR3; RZRA; NR1F1; IDDECA; RZR-ALPHA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6095

About RORA

Cytogenetic location: 15q22.2 Genomic coordinates (GRCh38): 15:60,488,284-61,229,302 (from NCBI)

This gene has 14 transcripts (splice variants), 395 orthologues, 18 paralogues and is associated with 2 phenotypes. Broad expression in skin (RPKM 15.9), adrenal (RPKM 10.1) and 21 other tissues.

Summary

The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, as well as with NM23-1, the product of a tumor metastasis suppressor candidate gene. Also, it has been shown to aid in the transcriptional regulation of some genes involved in circadian rhythm. Four transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Feb 2014]

RORA Products (11)

mRNA	Protein	Name
XM_047432928.1	XP_047288884.1	nuclear receptor ROR-alpha isoform X4
XM_011521877.4	XP_011520179.1	nuclear receptor ROR-alpha isoform X3
NM_134260.3	NP_599022.1	nuclear receptor ROR-alpha isoform b
XM_011521874.2	XP_011520176.1	nuclear receptor ROR-alpha isoform X1
XM_011521879.4	XP_011520181.1	nuclear receptor ROR-alpha isoform X5
NM_134261.3	NP_599023.1	nuclear receptor ROR-alpha isoform a
XM_011521875.3	XP_011520177.1	nuclear receptor ROR-alpha isoform X2
XM_047432929.1	XP_047288885.1	nuclear receptor ROR-alpha isoform X4
XM_047432930.1	XP_047288886.1	nuclear receptor ROR-alpha isoform X4
NM_002943.4	NP_002934.1	nuclear receptor ROR-alpha isoform c
NM_134262.3	NP_599024.1	nuclear receptor ROR-alpha isoform d

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables DNA binding	IDA IDA: Inferred from direct assay	7926749	GOA
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7926749	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21628546	GOA
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	19955433	GOA
enables ligand-activated transcription factor activity	IDA IDA: Inferred from direct assay	19965867	GOA
enables oxysterol binding	IDA IDA: Inferred from direct assay	19965867	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9862959	GOA
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	11053433	GOA
enables transcription coactivator binding	IPI IPI: Inferred from physical interaction	9862959	GOA
enables transcription coregulator binding	IPI IPI: Inferred from physical interaction	14701856	GOA
enables transcription corepressor binding	IPI IPI: Inferred from physical interaction	9328355	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in angiogenesis	IMP IMP: Inferred from mutant phenotype	18658046	GOA
involved in cellular response to hypoxia	IMP IMP: Inferred from mutant phenotype	18658046	GOA
involved in cellular response to sterol	IDA IDA: Inferred from direct assay	19965867	GOA
involved in cellular response to sterol	IMP IMP: Inferred from mutant phenotype	18658046	GOA
involved in intracellular receptor signaling pathway	IDA IDA: Inferred from direct assay	19965867	GOA
involved in muscle cell differentiation	IMP IMP: Inferred from mutant phenotype	9862959	GOA
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	11252722	GOA
involved in negative regulation of inflammatory response	IMP IMP: Inferred from mutant phenotype	11252722	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7926749	GOA
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17545671	GOA
involved in positive regulation of vascular endothelial growth factor production	IMP IMP: Inferred from mutant phenotype	18658046	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9328355	GOA
involved in triglyceride homeostasis	IMP IMP: Inferred from mutant phenotype	11053433	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	18658046	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RORA Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
523 a.a.

Protein Preferred Names	Protein Names
nuclear receptor ROR-alpha	ROR-alpha nuclear receptor RZR-alpha nuclear receptor subfamily 1 group F member 1 retinoic acid receptor-related orphan receptor alpha retinoid-related orphan receptor alpha transcription factor RZR-alpha

RORA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RORA	P35398	GFAP	Homo sapiens	P14136	Y2H Prey Pooling	25416956
Intra	RORA	P35398	NR0B1	Homo sapiens	P51843	Pull Down	16713569

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Epilepsy	Epilepsy Syndrome Epileptic Syndrome Epilepsies Symptomatic Epilepsies Post Traumatic Epilepsy Traumatic Epilepsy Traumatic Epileptic Epilepsy Due To Hippocampal Sclerosis Epilepsy With Ammon'S Horn Sclerosis Epilepsy Due To Cortical Dysplasia Epilepsy Due To Neuronal Migration Disorders
Bipolar Disorder	Bipolar Depression Manic Disorder Depression, Bipolar Bipolar Disorder Manic Phase Depressive-Manic Psych. Manic Bipolar Affective Disorder Manic Bipolar I Disorder Manic Depression Manic Depressive Disorder Mixed Bipolar Disorder Bipolar Affective Disorder Bipolar Affective Psychosis Bipolar Spectrum Disorder Manic Depressive Illness Depression Bipolar Bipolar Disorder, Mixed Major Affective Disorder Major Affective Disorder 1 Major Affective Disorder 2
Spinocerebellar Ataxia 1	Spinocerebellar Ataxia Type 1 SCA1 Olivopontocerebellar Atrophy I Opca1 Opca4 Menzel Type Opca Schut-Haymaker Type Opca Spinocerebellar Atrophy I Opca I Olivopontocerebellar Atrophy Iv Opca Iv Cerebelloparenchymal Disorder I Cpd1 Olivopontocerebellar Atrophy 1 Cerebelloparenchymal Disorder 1 Olivopontocerebellar Atrophy 4 Spinocerebellar Atrophy 1 Type 1 Spinocerebellar Ataxia Spinocerebellar Ataxia-1 Ataxia, Spinocerebellar, Type 1
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Asthma	Chronic Obstructive Asthma Asthma, Diminished Response To Antileukotriene Treatment In Bronchial Hyperreactivity Asthma, Susceptibility To Asthma, Bronchial Asthma, Protection Against Asthma, Nocturnal, Susceptibility To Nocturnal Asthma Asthma-Related Traits Asthma-Related Traits, Susceptibility To Asthma, Nocturnal Chronic Obstructive Asthma With Acute Exacerbation Chronic Obstructive Asthma With Status Asthmaticus Exercise Induced Asthma Exercise-Induced Asthma Bronchial Asthma Asthma, Exercise-Induced Idiosyncratic Asthma Unspecified Asthma With Acute Exacerbation Asthma, Unspecified, With Stated Status Asthmaticus Status Asthmaticus Nos Acute Severe Asthma Acute Severe Bronchial Asthma Status Asthma Status Post Asthmaticus
Intellectual Developmental Disorder With Or Without Epilepsy Or Cerebellar Ataxia	IDDECA
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Bronchiectasis 3
Robinow Syndrome, Autosomal Recessive 1	Robinow Syndrome, Autosomal Recessive Autosomal Recessive Robinow Syndrome Covesdem Syndrome RRS1 Costovertebral Segmentation Defect-Mesomelia Syndrome Rrs Costovertebral Segmentation Defect With Mesomelia, Formerly Covesdem Syndrome, Formerly Costovertebral Segmentation Defect With Mesomelia Robinow Syndrome Autosomal Recessive With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome Autosomal Recessive With Brachy-Syn-Polydactyly Robinow Syndrome, Autosomal Recessive, With Aplasia/Hypoplasia Of Phalanges And Metacarpals/Metatarsals Robinow Syndrome, Autosomal Recessive, With Brachy-Syn-Polydactyly Robinow, Autosomal Recessive Syndrome, Type 1
Epidermolysis Bullosa Acquisita	Acquired Epidermolysis Bullosa Eb Acquisita Eba Eba - [Epidermolysis Bullosa Acquisita]
Major Depressive Disorder	Seasonal Affective Disorder Unipolar Depression Depression MDD Depressive Disorder Unipolar Depression, Susceptibility To Major Depressive Disorder 1 Major Depressive Disorder, Response To Citalopram Therapy In Major Depressive Disorder 2 Winter Depression Single Major Depressive Episode Sad Clinical Depression Major Depression Depressive Syndrome Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment Seasonal Affective Disorder, Susceptibility To Recurrent Major Depression Affective Disorder, Seasonal Depression In A Seasonal Pattern Depression Seasonal Major Depressive Disorder With A Seasonal Pattern Seasonal Depression Seasonal Mood Disorder Mental Depression Recurrent Major Depressive Episodes
Advanced Sleep Phase Syndrome	Fasps Familial Advanced Sleep-Phase Syndrome Advanced Sleep Phase Syndrome, Familial Familial Advanced Sleep Phase Syndrome Sleep Phase Syndrome, Advanced, Familial Advanced Sleep-Phase Syndrome, Familial

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-402601	Desethyl-SID 7969543	Control	98.83%	Unkown
HY-RS12126	RORA Human Pre-designed siRNA Set A		/	Unkown
HY-RS12127	Rora Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS12128	RORA Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	RORA	VGNC	VGNC:76717
Felis catus	RORA	VGNC	VGNC:64721
Canis familiaris	RORA	VGNC	VGNC:45695
Mus musculus	RORA	MGD	MGI:104661
Rattus norvegicus	RORA	RGD	RGD:1308419
Bos taurus	RORA	VGNC	VGNC:34088
Others	RORA	NCBI