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Cat. No.: HY-130683

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Lenalidomide-propargyl-C2-NH2 hydrochloride

1 Cited Publications

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Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312). Lenalidomide-propargyl-C2-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Purity: 98.01%
CAS No.: 2489242-23-9
Formula: C₁₈H₂₀ClN₃O₃
Molecular Weight:361.82

Storage:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lenalidomide-propargyl-C2-NH2 hydrochloride Chemical Structure

CAS No.: 2489242-23-9

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Publications (1)
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Description

Lenalidomide-propargyl-C2-NH2 hydrochloride incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase, and a linker. Lenalidomide-propargyl-C2-NH2 hydrochloride can be used to design the PROTAC MD-224 (HY-114312)^[1]. Lenalidomide-propargyl-C2-NH2 (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC₅₀ & Target^[1]

Cereblon

All E3 Ligase Ligand-Linker Conjugates Isoforms :

Chemical Information

CAS No. 2489242-23-9
Appearance Solid
Molecular Weight 361.82
Formula C₁₈H₂₀ClN₃O₃
Color Off-white to light yellow
SMILES

O=C(C(N(CC1=C2C=CC=C1C#CCCCN)C2=O)CC3)NC3=O.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (1)

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Nat Commun

PROTAC repurposing uncovers a noncanonical binding surface that mediates chemical degradation of nuclear receptors. [Abstract]

2025 Nov 6;16(1):9805. PMID: 41198675

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (269 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Li Y, et al. Discovery of MD-224 as a First-in-Class, Highly Potent, and Efficacious Proteolysis TargetingChimera Murine Double Minute 2 Degrader Capable of Achieving Complete and Durable TumorRegression. J Med Chem. 2019 Jan 24;62(2):448-466. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Lenalidomide-propargyl-C2-NH2 hydrochloride

1 Cited Publications

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Lenalidomide-propargyl-C2-NH2 hydrochloride

Molecular Glue-like Compound Library

Publications Citing Use of MedChemExpress (MCE) Lenalidomide-propargyl-C2-NH2 hydrochloride

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

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Help & FAQs

Lenalidomide-propargyl-C2-NH2 hydrochloride

Molecular Glue-like Compound Library

Publications Citing Use of MedChemExpress (MCE) Lenalidomide-propargyl-C2-NH2 hydrochloride

All E3 Ligase Ligand-Linker Conjugates Isoforms

Biological Activity

Chemical Information

Publications (1)

Purity & Documentation

References

Calculators

Help & FAQs

Lenalidomide-propargyl-C2-NH2 hydrochloride Related Classifications

Cat. No.: HY-130683