1. Anti-infection
  2. Fungal
  3. Caspofungin Acetate

Caspofungin Acetate (Synonyms: L 743872; L 743873; MK 0991)

Cat. No.: HY-17006 Purity: 99.79%
Handling Instructions

Caspofungin (Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.

For research use only. We do not sell to patients.

Caspofungin Acetate Chemical Structure

Caspofungin Acetate Chemical Structure

CAS No. : 179463-17-3

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5 mg USD 66 In-stock
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10 mg USD 96 In-stock
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Customer Review

Based on 2 publication(s) in Google Scholar

Top Publications Citing Use of Products

Publications Citing Use of MCE Caspofungin Acetate

    Caspofungin Acetate purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2016 Aug 12;39(3):939-949.

    Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).
    • Biological Activity

    • Protocol

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Caspofungin (Acetate) is an antifungal drug, and noncompetitively inhibits 1,3-β-d glucan synthase activity.

    In Vivo

    Mice injected with caspofungin at vitreal concentrations from 0.41 to 4.1 μM do not have significant alterations in their ERG waveforms, and their retinas have no detectable morphologic changes or loss of cells. At the vitreal concentration of 41 μM, caspofungin reduces the amplitudes of the a-waves, b-waves, and scotopic threshold responses of the ERG and also produces a decrease in the number of cells in the ganglion cell layer[1]. Caspofungin (8 mg/kg) or amphotericin B at 1 mg/kg given i.p. once daily for 7 days beginning at 30 h after infection resulted in 100% survival through day 28 relative to vehicle control treatment, which results in 100% mortality by day 11 after infectious challenge. Caspofungin reduces recovery of viable Candida from kidney and brain tissues compared to vehicle control treatment on day 5, when control burden peaked. Caspofungin-treated mice dosed with 2 mg/kg or greater have significantly lower brain burden than amphotericin-B-treated mice at day 5. Amphotericin B and caspofungin treatment reduce kidney fungal burden by 1.7 log CFU/g and 2.46 to 3.64 log CFU/g, respectively[2].

    Clinical Trial
    Molecular Weight

    1213.42

    Formula

    C₅₆H₉₆N₁₀O₁₉

    CAS No.

    179463-17-3

    SMILES

    OC1=CC=C(C=C1)[[email protected]]([[email protected]@H]([[email protected]@H]2NC([[email protected]@H]3C[[email protected]](CN3C([[email protected]]([[email protected]](O)C)NC([[email protected]](C[[email protected]]([[email protected]@H](NCCN)NC([[email protected]@H]4[[email protected]](CCN4C([[email protected]]([[email protected]](O)CCN)NC2=O)=O)O)=O)O)NC(CCCCCCCCC(CC(CC)C)C)=O)=O)=O)O)=O)O)O.OC(C)=O.OC(C)=O

    Shipping

    Room temperature in continental US; may vary elsewhere.

    Storage

    -70°C

    *The compound is unstable in solutions, freshly prepared is recommended.

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (82.41 mM)

    DMSO : ≥ 83.3 mg/mL (68.65 mM)

    *"≥" means soluble, but saturation unknown.

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8241 mL 4.1206 mL 8.2412 mL
    5 mM 0.1648 mL 0.8241 mL 1.6482 mL
    10 mM 0.0824 mL 0.4121 mL 0.8241 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (1.71 mM); Clear solution

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.08 mg/mL (1.71 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (1.71 mM); Clear solution

    *All of the co-solvents are provided by MCE.
    References
    Animal Administration
    [2]

    Antifungal therapy is initiated at 30 h after infectious challenge and is given by intraperitoneal (i.p.) injection once daily for 7 days. Mice are treated with caspofungin at 1, 2, 4, or 8 mg/kg/day, amphotericin B at 1 mg/kg/day, or vehicle control (sterile distilled water). Efficacy in this model is assessed in 3 ways: by monitoring survival in a group of 10 animals in each treatment group, by monitoring Candida burden in kidney and brain tissues in a second set of treated animals, and by histologically evaluating the kidneys and brains in a third set of treated animals. Mice are euthanized by CO2 inhalation, and tissues for both culture and histology are sampled at 30 h (vehicle-treated control only) and at days 5 (24 h after 4th dose), 8 (24 h after last dose), 14, 21 (caspofungin-treated only), and 28 after challenge.

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    References

    Purity: 99.79%

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    Keywords:

    CaspofunginL 743872L 743873MK 0991L743872L-743872L743873L-743873MK0991MK-0991FungalInhibitorinhibitorinhibit

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    Product name:
    Caspofungin Acetate
    Cat. No.:
    HY-17006
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