1. Anti-infection
  2. Fungal Antibiotic Bacterial
  3. Caspofungin diacetate

Caspofungin diacetate  (Synonyms: MK-0991 diacetate; L-743872 diacetate)

Cat. No.: HY-17006 Purity: 99.63%
COA Handling Instructions

Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan.

For research use only. We do not sell to patients.

Caspofungin diacetate Chemical Structure

Caspofungin diacetate Chemical Structure

CAS No. : 179463-17-3

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Customer Review

Based on 4 publication(s) in Google Scholar

Other Forms of Caspofungin diacetate:

Top Publications Citing Use of Products

    Caspofungin diacetate purchased from MCE. Usage Cited in: Cell Physiol Biochem. 2016 Aug 12;39(3):939-949.  [Abstract]

    Arithmetic means±SEM (n=21) of erythrocyte annexin-V-binding following incubation for 48 hours to Ringer solution without (white bar) or with (black bars) Caspofungin (30-60 µg/mL).
    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review


    Caspofungin (MK-0991) diacetate is a potent antifungal agent. Caspofungin diacetate inhibits the synthesis of the fungal cell wall component β-(l,3)-D-glucan[1][2].

    In Vivo

    Caspofungin diacetate (1-8 mg/kg; i.p.; daily, for 7 days) is able to penetrate the CNS in mice and achieve concentrations that result in the reduction of Candida burden in the brain[1].
    Caspofungin diacetate (0.41-41 μM; i.p.; for 5 weeks; male C57BL/6 mice) is a safe antifungal agent at vitreal concentrations of 0.41 to 4.1 μM in mice[2].

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Complement component 5-deficient DBA/2N mice[1]
    Dosage: 1, 2, 4 and 8 mg/kg
    Administration: Intraperitoneal injection; daily, for 7 days
    Result: Reduced the concentration of Candida load in the brain.
    Animal Model: Male C57BL/6 mice[2]
    Dosage: 0.41, 1.2, 2.5, 4.1, and 41 μM
    Administration: Intraperitoneal injection; for 5 weeks
    Result: Had nonsignificant alterations in their ERG waveforms from 0.41 to 4.1 μM.
    Clinical Trial
    Molecular Weight






    CAS No.



    Room temperature in continental US; may vary elsewhere.


    -20°C, sealed storage, away from moisture and light

    *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

    Solvent & Solubility
    In Vitro: 

    H2O : ≥ 100 mg/mL (82.41 mM)

    DMSO : 100 mg/mL (82.41 mM; Need ultrasonic)

    *"≥" means soluble, but saturation unknown.

    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 0.8241 mL 4.1206 mL 8.2412 mL
    5 mM 0.1648 mL 0.8241 mL 1.6482 mL
    10 mM 0.0824 mL 0.4121 mL 0.8241 mL
    *Please refer to the solubility information to select the appropriate solvent.
    In Vivo:
    • 1.

      Add each solvent one by one:  PBS

      Solubility: 100 mg/mL (82.41 mM); Clear solution; Need ultrasonic

    • 2.

      Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

      Solubility: ≥ 2.5 mg/mL (2.06 mM); Clear solution

    • 3.

      Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

      Solubility: ≥ 2.08 mg/mL (1.71 mM); Clear solution

    • 4.

      Add each solvent one by one:  10% DMSO    90% corn oil

      Solubility: ≥ 2.08 mg/mL (1.71 mM); Clear solution

    *All of the co-solvents are available by MCE.
    Purity & Documentation

    Purity: 99.79%

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    Caspofungin diacetate Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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    This equation is commonly abbreviated as: C1V1 = C2V2

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