1. GPCR/G Protein
  2. Prostaglandin Receptor
  3. Misoprostol

Misoprostol  (Synonyms: SC-29333)

Cat. No.: HY-B0610
Handling Instructions

Misoprostol (SC-29333) is an orally active synthetic prostaglandin E1 (PGE1) analog that is used for gastric ulcers research.

For research use only. We do not sell to patients.

Misoprostol Chemical Structure

Misoprostol Chemical Structure

CAS No. : 59122-46-2

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10 mg USD 90 Ask For Quote & Lead Time
25 mg USD 180 Ask For Quote & Lead Time
50 mg USD 290 Ask For Quote & Lead Time
100 mg USD 460 Ask For Quote & Lead Time

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Description

Misoprostol (SC-29333) is an orally active synthetic prostaglandin E1 (PGE1) analog that is used for gastric ulcers research[1].

IC50 & Target

Prostaglandin Receptor[1]

In Vitro

Misoprostol (SC-29333) is a synthetic analog of natural prostaglandin E1. It produces a dose-related inhibition of gastric acid and pepsin secretion, and enhances mucosal resistance to injury. It is an effective anti-ulcer agent and also has oxytocic properties. Misoprostol seems to inhibit gastric acid secretion by a direct action on the parietal cells through binding to the prostaglandin receptor. Administration of misoprostol to EP3+/+ and EP3-/- mice showed similar levels of infarct rescue, indicating that misoprostol protection was not mediated through the EP3 receptor. Taken together, these findings suggest a novel function for misoprostol as a protective agent in cerebral ischemia acting via the PGE(2) EP2 and/or EP4 receptors[1][2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

382.53

Formula

C22H38O5

CAS No.
SMILES

O[[email protected]](C1)[[email protected]@H]([[email protected]](C1=O)CCCCCCC(OC)=O)/C=C/CC(C)(O)CCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (65.35 mM; Need ultrasonic)

H2O : 2 mg/mL (5.23 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6142 mL 13.0709 mL 26.1417 mL
5 mM 0.5228 mL 2.6142 mL 5.2283 mL
10 mM 0.2614 mL 1.3071 mL 2.6142 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (6.54 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.44 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (5.44 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Misoprostol
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HY-B0610
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