1. GPCR/G Protein
    Neuronal Signaling
  2. Opioid Receptor
  3. Nalfurafine

Nalfurafine (Synonyms: TRK-820)

Cat. No.: HY-12745
Handling Instructions

Nalfurafine (TRK-820) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential. Nalfurafine (TRK-820) enhances the therapeutic potential of MOR-targeting analgesics, has the potential for uremic pruritis treatment.

For research use only. We do not sell to patients.

Nalfurafine Chemical Structure

Nalfurafine Chemical Structure

CAS No. : 152657-84-6

Size Price Stock
5 mg USD 432 Ask For Quote & Lead Time
10 mg USD 780 Ask For Quote & Lead Time
50 mg USD 2160 Ask For Quote & Lead Time

* Please select Quantity before adding items.

Other In-stock Forms of Nalfurafine:

Other Forms of Nalfurafine:

Top Publications Citing Use of Products
  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nalfurafine (TRK-820) is a potent selective and orally active G protein-biased kappa opioid receptor (KOR)-agonist with high translational potential[1]. Nalfurafine (TRK-820) enhances the therapeutic potential of MOR-targeting analgesics, has the potential for uremic pruritis treatment[2].

IC50 & Target

IC50: kappa opioid receptor (KOR)[1]

In Vivo

Nalfurafine (subcutaneous injection; 0.015 mg/kg) combines with EOM-salvinorin-B  produces spinal antinociception equivalent to 5 mg/kg, it also enhances the supraspinal analgesic effect of 5 mg/kg morphine[1].
Nalfurafine (subcutaneous injection; 4 μg/kg) causes a dose-dependent increase of the inhibition of the acetic acid-induced abdominal constriction,and the inhibition of the abdominal constriction reaches its peak 30 min after injection, gradually declined and returned to the preinjection level 4 hr after[2].

Animal Model: Male and Female C57BL/6J mice[1]
Dosage: 0.015 mg/kg
Administration: Subcutaneous injection
Result: Had the potential for enhancing the therapeutic potential of MOR-targeting analgesics, such as morphine.
Clinical Trial
Molecular Weight

476.56

Formula

C₂₈H₃₂N₂O₅

CAS No.

152657-84-6

SMILES

O[[email protected]@]1(CC[[email protected]@H](N(C)C(/C=C/C2=COC=C2)=O)[[email protected]]3([H])OC4=C5O)[[email protected]]63C4=C(C=C5)C[[email protected]@]1([H])N(CC7CC7)CC6

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.
  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

NalfurafineTRK-820TRK820TRK 820Opioid ReceptoragonistanalgesicuremicpruritisInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product name

 

Salutation

Applicant name *

 

Email address *

Phone number *

 

Organization name *

Country or Region *

 

Requested quantity *

Remarks

Bulk Inquiry

Inquiry Information

Product name:
Nalfurafine
Cat. No.:
HY-12745
Quantity:
MCE Japan Authorized Agent: