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Aromatase

Aromatase (also known as CYP19) is a member of the general class of cytochrome P450 enzymes. It catalyzes the conversion of androgens to estrogens, which is a crucial step in the biosynthesis of estrogens in the human body.

Aromatase enzyme is expressed in ovarian granulosa cells, placental syncytiotrophoblast, adipose tissue, brain, and skin fibroblasts. The primary sources of aromatase are ovarian granulosa cells in premenopausal women and adipose cells in postmenopausal women. Aromatase inhibitors suppress oestrogen synthesis in the ovaries and in peripheral tissues, starting from the next day after dosing. They work by inhibiting the action of aromatase, which converts androgens into oestrogens (testosterone into estradiol and androstenedione into oestrone). There are three generations of aromatase inhibitors (AIs). Aminoglutethimide is a first-generation aromatase inhibitor. The second-generation inhibitors include Fadrozole and Formestane. Anastrozole, Letrozole, and Exemestane are third-generation inhibitors.

Aromatase is encoded by the cyp19a1 gene, belongs to a particular reticulum-bound cytochrome P450 superfamily and forms an electron-transfer complex with its partner, NADPH-cytochrome P450 reductase (CPR).

Aromatase Related Products (7):

Cat. No. Product Name Effect Purity
  • HY-14248
    Letrozole Inhibitor 99.91%
    Letrozole(CGS-20267) is an oral non-steroidal aromatase inhibitor that has been introduced for the adjuvant.
  • HY-14274
    Anastrozole Inhibitor 99.79%
    Anastrozole is a potent, highly selective aromatase inhibitor, which inhibits human placental aromatase with an IC50 of 15 nM.
  • HY-B0697
    Formestane Inhibitor 99.87%
    Formestane(CGP-32349; 4-OHA) is a selective, type I, steroidal aromatase inhibitor used in the treatment of estrogen-receptor positive breast cancer.
  • HY-13632
    Exemestane Inhibitor
    Exemestane(FCE 24304) is an aromatase inhibitor, inhibits human placental and rat ovarian aromatase with IC50 of 30 nM and 40 nM, respectively.
  • HY-B0237
    Aminoglutethimide Inhibitor
    Aminoglutethimide is an aromatase inhibitor with IC50 of 10 μM.
  • HY-14247A
    Fadrozole Inhibitor 99.78%
    Fadrozole is a potent, selective and nonsteroidal inhibitor of aromatase with an IC50 of 6.4 nM.
  • HY-U00176
    Org30958 Inhibitor
    Org30958 is a potent aromatase inhibitor in vivo.