PROTAC Linkers
PROTACs (Proteolysis Targeting Chimeric Molecules) are heterobifunctional protein degraders and promising targeted therapeutics candidates for cancer. The PROTAC linker connects two functional motifs of a PROTAC, a target protein binder and an E3 ligase recruiter.
The linker plays an important role in a PROTAC. The features of the linker (type, length, attachment position) can affect the formation of ligase:PROTAC:target ternary complex, resulting in influencing the efficient ubiquitination of the target protein and its ultimate degradation. The optimal lengths of the PROTAC linkers are reported varying from 12-carbon to over 20-carbon, and the commonly used linkers in the development of PROTACs are PEGs, Alkyl-Chain and Alkyl/ether.
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PROTAC Linkers Verwandte Produkte (4114)
Verwandte Produkte (4114)
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PROTAC Linkers Isoform Comparison
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Br-PEG4-C2-Boc
0 ImagesBr-PEG4-C2-Boc is a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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7-Octynoic acid
0 Images7-Octynoic acid (compound 42) is a PROTAC linker and can be used in the synthesis of a series of PROTACs. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins. 7-Octynoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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NH2-PEG2-CH2-Boc
0 ImagesArt. -Nr.: HY-42427CAS. Nr.: 1948273-09-3
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H-Glu-OtBu
0 ImagesH-Glu-OtBu is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). H-Glu-OtBu is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[2
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1-Cbz-azetidine-3-carboxylic acid
0 Images1-Cbz-azetidine-3-carboxylic acid is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). 1-Cbz-azetidine-3-carboxylic acid is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]-
Boc-NH-PEG4
0 ImagesSynonyms: PROTAC Linker 12
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Bromo-PEG3-C2-acid
0 ImagesArt. -Nr.: HY-W039168CAS. Nr.: 782475-35-8
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Fmoc-NH-PEG2-C2-NH2 hydrochloride
0 ImagesArt. -Nr.: HY-W021402CAS. Nr.: 868599-73-9
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4-(Aminoethyl)-1-N-Boc-piperidine
0 ImagesArt. -Nr.: HY-40335CAS. Nr.: 146093-46-1
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