Squalene Monooxygenase

Squalene Monooxygenase, SQLE, Squalene Epoxidase

Squalene epoxidase (SQLE), also named squalene monooxygenase, is a FAD-containing enzyme in the endoplasmatic reticulum. SQLE catalyzes the epoxidation of squalene to produce 2,3-oxidosqualene in the presence of NADPH, a key step in cholesterol biosynthesis. SQLE is a direct target of SREBP2 transcription factor that regulates the majority of genes in the cholesterol biosynthetic pathway^[1]^[2].

References:

[1]. Nikhilesh Arya, et al. Some molecular targets for antihyperlipidemic drug research. Eur J Med Chem. 2014 Oct 6:85:535-68. [Content Brief]

[2]. Anil K Padyana, et al. Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun. 2019 Jan 9;10(1):97. [Content Brief]

Squalene Monooxygenase Inhibitors (3)

Squalene Monooxygenase Related Products (3):

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-100303A

FR194738	Inhibitor	98.76%
FR194738 is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

HY-W020246

Tetramethylthiuram monosulfide	Inhibitor	99.71%
Tetramethylthiuram monosulfide (TMTM) is an orally active microsomal monooxygenases inhibitor. Tetramethylthiuram monosulfide is used as an accelerator and activator in the processing of natural rubber and butyl rubber. Tetramethylthiuram monosulfide reduces palmitic acid incorporation into microsomal phospholipids, disrupts microsomal membrane integrity, and impairs electron transport during oxygenation. Tetramethylthiuram monosulfide can be used for the research of fungal infection, bacterial infection and allergic contact dermatitis.

HY-100303

FR194738 free base	Inhibitor	99.84%
FR194738 free base is a squalene epoxidase inhibitor. FR194738 inhibits squalene epoxidase activity in HepG2 cell homogenates with an IC₅₀ of 9.8 nM.

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