11 Results for "

akt-in-13

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "akt-in-13" in MCE Product Catalog:

5
AKT-IN-1
AKT-IN-1
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5 Cited Publications
Cat. No.: HY-18296
CAS No.: 1357158-81-6
Target:  

Akt

Research Areas:  

Cancer

AKT-IN-1 is an allosteric AKT inhibitor with an IC50 of 1.042 μM.
AKT-IN-3
AKT-IN-3
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Cat. No.: HY-126257
CAS No.: 2374740-21-1
Purity:  99.29%
Target:  

Akt Apoptosis

Research Areas:  

Cancer

AKT-IN-3 (compound E22) is a potent, orally active low hERG blocking Akt inhibitor, with 1.4 nM, 1.2 nM and 1.7 nM for Akt1, Akt2 and Akt3, respectively. AKT-IN-3 (compound E22) also exhibits good inhibitory activity against other AGC family kinases, such as PKA, PKC, ROCK1, RSK1, P70S6K, and SGK. AKT-IN-3 (compound E22) induces apoptosis and inhibits metastasis of cancer cells .
AKT-IN-18
AKT-IN-18
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Cat. No.: HY-149842
Target:  

Akt Apoptosis

Research Areas:  

Cancer

AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC50 of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study .
AKT-IN-14
AKT-IN-14
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Cat. No.: HY-153640
CAS No.: 2781918-35-0
Target:  

Akt

Research Areas:  

Cancer

AKT-IN-14 (Example 2) is a potent AKTinhibitor with the IC50 values of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2, AKT3, respectively. AKT-IN-14 can be used in cancer research .
AKT-IN-23
AKT-IN-23
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Cat. No.: HY-161704
CAS No.: 1226801-23-5
Target:  

Akt

Research Areas:  

Cancer

AKT-IN-23 is an AKT inhibitor. AKT-IN-23 can be used in cancer research .
AKT-IN-12
AKT-IN-12
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Cat. No.: HY-147513
CAS No.: 2396718-52-6
Target:  

Akt Apoptosis

Research Areas:  

Cancer

AKT-IN-12 (compound 3e) is a potent Akt kinase inhibitor with an IC50 value of 0.55 μM. AKT-IN-12 induces G0/G1 cell cycle arrest and apoptosis. AKT-IN-12 also inhibits p-AKT, p-ERK, and activates p-JNK, JNK. AKT-IN-12 can be used for researching leukemia .
AKT-IN-10
AKT-IN-10
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Cat. No.: HY-144060
CAS No.: 2709045-56-5
Target:  

Akt

Research Areas:  

Cancer

AKT-IN-10 is a potent inhibitor of AKT. Protein kinase B (PKB, also known as AKT) is central to PI3K/AKT/mTOR signaling in cells, and its function is important for cell growth, survival, differentiation and metabolism. AKT-IN-10 has the potential for the research of breast and prostate cancer (extracted from patent WO2021185238A1, compound 4) .
AKT-IN-11
AKT-IN-11
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Cat. No.: HY-144253
Target:  

Akt ERK

Research Areas:  

Cancer

AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC50 value of 1.15μM.
AKT-IN-17
AKT-IN-17
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Cat. No.: HY-149841
Target:  

Akt

Research Areas:  

Cancer

AKT-IN-17 is a AKt inhibitor. AKT-IN-17 inhibits AKt in A549 cells, leading to Apoptosis. AKT-IN-17 can be used in non-small cell lung cancer study .
AKT-IN-14 free base
AKT-IN-14 free base
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Cat. No.: HY-153640A
CAS No.: 2781918-27-0
Target:  

Akt

Research Areas:  

Cancer

AKT-IN-14 (Example 2) free baseis a potent AKTinhibitor with the IC50 values of <0.01 nM, 1.06 nM and 0.66 nM for AKT1, AKT2, AKT3, respectively. AKT-IN-14 free basecan be used in cancer research .
AKT1-IN-13
AKT1-IN-13
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Cat. No.: HY-184145
Target:  

Akt PAK PKA MEK ERK Apoptosis Bcl-2 Family Caspase

Research Areas:  

Cancer

AKT1-IN-13 is an orally active AKT1 inhibitor with an IC50 of 5.17 μM. AKT1-IN-13 also exhibits high inhibitory activity against PAK1, PKA, MAP2K1 (MEK1 / MAPKK1) and MAPK1 (ERK2). AKT1-IN-13 induces cell apoptosis, activates the pro-apoptotic protein BAX, inhibits the anti-apoptotic protein Bcl-2, and activates caspase 3 simultaneously. As a cytotoxic agent, AKT1-IN-13 exerts a killing effect on orthotopically transplanted liver cancer in an AKT1-dependent manner. AKT1-IN-13 can be used in studies related to hepatocellular carcinoma .
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