AKT-IN-18
AKT-IN-18, an inhibitor of Akt, inhibits Akt with an IC50 of 69.45 μΜ in A549 cells. AKT-IN-18 induces apoptosis and can be used in non-small cell lung cancer study.
For research use only. We do not sell to patients.
- Formula: C19H14ClN5O2S
- Molecular Weight:411.86
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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Akt 69.45 μM (IC50) |
AKT-IN-18 (Compound 3i) (0-500 μM; 24 hours) exerts cytotoxic activity against A549 cells, and induces apoptosis [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549, L929 cells
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Concentration:0-500 μM
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Incubation Time:24 hours
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Result:Exerted cytotoxic activity against A549 cells with IC50 of 83.59 μΜ without influencing normal (L929) cells at effective doses.
Induced early apoptosis caused at 2.7% and late apoptotic cells at 6.04%.
Chemical Information
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Molecular Weight 411.86
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Formula C19H14ClN5O2S
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SMILES
O=C(N/N=C/C1=CC=C(N2C=CN=C2)C=C1)CSC3=NC4=CC(Cl)=CC=C4O3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AKT-IN-18 Related Classifications
HY-149842 Related Classifications
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