Cholestenone-13C
Based on 1 Customer Validation
Cholestenone-13C is the 13C labeled Cholestenone. Cholestenone (4-Cholesten-3-one), the intermediate oxidation product of cholesterol, is metabolized primarily in the liver. Cholestenone is highly mobile in membranes and influences cholesterol flip-flop and efflux. Cholestenone may cause long-term functional defects in cells.
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- Reinheit: 99.0%
- CAS. Nr.: 68165-57-1
- Formel: C2613CH44O
- Molecular Weight:385.63
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 68165-57-1
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Unlabeled Cas 601-57-0
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Appearance Solid
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Molecular Weight 385.63
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Formel C2613CH44O
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Color White to off-white
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SMILES
C[C@@]12[C@](CC[C@]2([H])[C@H](C)CCCC(C)C)([H])[C@@]3([H])[C@@](CC1)([H])[C@@]4(C(CC3)=[13CH]C(CC4)=O)C
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Synonyms
4-Cholesten-3-one-13C
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
Ethanol : 50 mg/mL (129.66 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (271 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]
[2]. Rosenheim O, et al. The mechanism of coprosterol formation in vivo: 1. Cholestenone as an intermediate. Biochem J. 1943 Oct;37(4):513-4. [Content Brief]
[3]. Neuvonen M, et, al. Enzymatic oxidation of cholesterol: properties and functional effects of cholestenone in cell membranes. PLoS One. 2014 Aug 26;9(8):e103743. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| Ethanol | 1 mM | 2.5932 mL | 12.9658 mL | 25.9316 mL | 64.8290 mL |
| 5 mM | 0.5186 mL | 2.5932 mL | 5.1863 mL | 12.9658 mL | |
| 10 mM | 0.2593 mL | 1.2966 mL | 2.5932 mL | 6.4829 mL | |
| 15 mM | 0.1729 mL | 0.8644 mL | 1.7288 mL | 4.3219 mL | |
| 20 mM | 0.1297 mL | 0.6483 mL | 1.2966 mL | 3.2414 mL | |
| 25 mM | 0.1037 mL | 0.5186 mL | 1.0373 mL | 2.5932 mL | |
| 30 mM | 0.0864 mL | 0.4322 mL | 0.8644 mL | 2.1610 mL | |
| 40 mM | 0.0648 mL | 0.3241 mL | 0.6483 mL | 1.6207 mL | |
| 50 mM | 0.0519 mL | 0.2593 mL | 0.5186 mL | 1.2966 mL | |
| 60 mM | 0.0432 mL | 0.2161 mL | 0.4322 mL | 1.0805 mL | |
| 80 mM | 0.0324 mL | 0.1621 mL | 0.3241 mL | 0.8104 mL | |
| 100 mM | 0.0259 mL | 0.1297 mL | 0.2593 mL | 0.6483 mL |
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