Gnao1 - guanine nucleotide binding protein, alpha O Gene

Also Known as Gnao; Hg1g; alphaO; Galphao

Species: Mus musculus

Gene Type: protein coding
Gene ID: 14681

Summary

Enables GTP binding activity and GTPase activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; Dopamine Receptor signaling pathway; and locomotory behavior. Located in cell body and dendrite. Is expressed in several structures, including alimentary system; brain; ganglia; genitourinary system; and sensory organ. Used to study developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Apr 2022]

Gnao1 Products (2)

mRNA Protein Name
NM_001113384.1 NP_001106855.1 guanine nucleotide-binding protein G(o) subunit alpha isoform B
NM_010308.3 NP_034438.1 guanine nucleotide-binding protein G(o) subunit alpha isoform A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables G protein activity IDA
IDA: Inferred from direct assay
10926822 MGI
enables GTP binding IMP
IMP: Inferred from mutant phenotype
11248120 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
10926822 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within G protein-coupled dopamine receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
11248120 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
9501252 MGI
acts upstream of or within locomotory behavior IMP
IMP: Inferred from mutant phenotype
9501252 MGI
involved in negative regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
20622165 MGI
involved in postsynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
33535037 MGI
involved in postsynaptic modulation of chemical synaptic transmission IMP
IMP: Inferred from mutant phenotype
33535037 MGI
acts upstream of or within regulation of heart contraction IMP
IMP: Inferred from mutant phenotype
9050846 MGI
acts upstream of negative effect vesicle docking involved in exocytosis IMP
IMP: Inferred from mutant phenotype
20622165 MGI
Cellular Component GO Annotation Evidence Verweise Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
34248508 MGI
located in cell body IDA
IDA: Inferred from direct assay
11685543 MGI
located in dendrite IDA
IDA: Inferred from direct assay
11685543 MGI
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
34248508 MGI
is active in parallel fiber to Purkinje cell synapse IDA
IDA: Inferred from direct assay
34248508 MGI
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
34248508 MGI
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
34248508 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

guanine nucleotide-binding protein G(o) subunit alpha

  • GTP-binding protein alpha-o subunit

  • Go alpha

  • heterotrimeric guanine nucleotide-binding protein 1g

Recombinant Gnao1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P72207 GNAO1 Protein, Mouse (His) P18872 (G2-Y354) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS05538 GNAO1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18822 Gnao1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25312 Gnao1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gnao1 NCBI NCBI:2775