GNAO1 Protein, Mouse (His)
GNAO1 protein is a member of G proteins and plays a vital role in regulating or transducing signals in a variety of transmembrane signaling systems, but the specific function of G(o) proteins remains unclear. G proteins have three units—alpha, beta, and gamma—that mediate cellular responses. GNAO1 Protein, Mouse (His) is the recombinant mouse-derived GNAO1 protein, expressed by E. coli , with N-6*His labeled tag.
- Species: Mouse
- Source: E. coli
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
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Biological Activity
Description
GNAO1 protein is a member of G proteins and plays a vital role in regulating or transducing signals in a variety of transmembrane signaling systems, but the specific function of G(o) proteins remains unclear. G proteins have three units—alpha, beta, and gamma—that mediate cellular responses. GNAO1 Protein, Mouse (His) is the recombinant mouse-derived GNAO1 protein, expressed by E. coli , with N-6*His labeled tag.
Background
GNAO1, a member of guanine nucleotide-binding proteins (G proteins), serves as a crucial modulator or transducer in diverse transmembrane signaling systems, although the specific function of the G(o) protein remains unclear. Comprising three units—alpha, beta, and gamma—G proteins play an essential role in mediating cellular responses to extracellular signals. The alpha chain of GNAO1 hosts the guanine nucleotide binding site, a key element in its regulatory activity. GNAO1 forms a complex with GNB1 and GNG3, highlighting the intricate interplay within the G protein structure. Furthermore, GNAO1 is stimulated by RGS14 and interacts with regulatory proteins like RGS19, further elucidating its involvement in finely tuned signal modulation.
Technical Parameters
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Species Mouse
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Source E. coli
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Tag N-6*His
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Accession
P18872 (G2-Y354)
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Molecular Construction
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N-term
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6*His
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GNAO1 (G2-Y354)
Accession # P18872 -
C-term
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Protein Length
Full Length of Isoform-1
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Synonyms
GNAO1; GO2-Q Chimeric G-Protein; G Protein Subunit Alpha O1; EIEE17; Guanine Nucleotide-Binding Protein G(O) Subunit Alpha; DEE17; G-ALPHA-O; NEDIM; Guanine Nucleotide Binding Protein (G Protein), Alpha Activating Activity Polypeptide O; GNAO; Heterotrime
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AA Sequence
GCTLSAEERAALERSKAIEKNLKEDGISAAKDVKLLLLGAGESGKSTIVKQMKIIHEDGFSGEDVKQYKPVVYSNTIQSLAAIVRAMDTLGVEYGDKERKTDSKMVCDVVSRMEDTEPFSAELLSAMMRLWGDSGIQECFNRSREYQLNDSAKYYLDSLDRIGAGDYQPTEQDILRTRVKTTGIVETHFTFKNLHFRLFDVGGQRSERKKWIHCFEDVTAIIFCVALSGYDQVLHEDETTNRMHESLMLFDSICNNKFFIDTSIILFLNKKDLFGEKIKKSPLTICFPEYPGSNTYEDAAAYIQTQFESKNRSPNKEIYCHMTCATDTNNIQVVFDAVTDIIIANNLRGCGLY
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Predicted Molecular Mass
44 kDa
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Purity
≥ 90%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O.
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US;may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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