EXD1 - exonuclease 3'-5' domain containing 1 Gene

Also Known as EXDL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 161829

About EXD1

This gene has 5 transcripts (splice variants), 182 orthologues and 1 paralogue. Restricted expression toward testis (RPKM 6.1).

Summary

Predicted to enable RNA binding activity and protein homodimerization activity. Predicted to be involved in gene silencing by RNA and piRNA metabolic process. Predicted to be located in P granule. Predicted to be part of PET complex. [provided by Alliance of Genome Resources, Apr 2022]

EXD1 Products (3)

mRNA Protein Name
NM_001286441.2 NP_001273370.1 piRNA biogenesis protein EXD1 isoform 1
NM_001385036.1 NP_001371965.1 piRNA biogenesis protein EXD1 isoform 3
NM_152596.4 NP_689809.2 piRNA biogenesis protein EXD1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EXD1 Protein Structure

DNA_pol_A_exo1

DNA_pol_A_exo1: 3'-5' exonuclease (85 - 210)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 514 a.a.
Protein Preferred Names Protein Names

piRNA biogenesis protein EXD1

  • exonuclease 3'-5' domain-containing protein 1

EXD1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
EXD1 Q8NHP7 EML2 Homo sapiens O95834
Y2H Array
25416956
Intra
EXD1 Q8NHP7 EML2 Homo sapiens O95834
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cerebral Creatine Deficiency Syndrome 3

  • Arginine:Glycine Amidinotransferase Deficiency

  • Agat Deficiency

  • Gatm Deficiency

  • Creatine Deficiency Syndrome Due To Agat Deficiency

  • L-Arginine:Glycine Amidinotransferase Deficiency

  • CCDS3

  • L-Arginine:Glycine Aminidotransferase Deficiency

  • Deficiency, Cerebral Creatine, Syndrome, Type 3
Cerebral Creatine Deficiency Syndrome

  • Deficiency, Cerebral Creatine, Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04582 EXD1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus EXD1 VGNC VGNC:61995
Macaca mulatta EXD1 VGNC VGNC:72390
Bos taurus EXD1 VGNC VGNC:28639
Canis familiaris EXD1 VGNC VGNC:40508
Rattus norvegicus EXD1 RGD RGD:1561009
Mus musculus EXD1 MGD MGI:3045306
Others EXD1 NCBI