EML2 - EMAP like 2 Gene

Also Known as ELP70; EMAP2; EMAP-2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 24139

About EML2

Cytogenetic location: 19q13.32 Genomic coordinates (GRCh38): 19:45,609,400-45,645,629 (from NCBI)

This gene has 31 transcripts (splice variants), 187 orthologues and 9 paralogues. Ubiquitous expression in esophagus (RPKM 8.7), skin (RPKM 8.5) and 25 other tissues.

Summary

Enables microtubule binding activity. Involved in negative regulation of microtubule polymerization and regulation of microtubule nucleation. Colocalizes with mitotic spindle. [provided by Alliance of Genome Resources, Apr 2022]

EML2 Products (7)

mRNA Protein Name
NM_001193268.3 NP_001180197.1 echinoderm microtubule-associated protein-like 2 isoform 1
NM_001193269.2 NP_001180198.1 echinoderm microtubule-associated protein-like 2 isoform 3
NM_001352051.2 NP_001338980.1 echinoderm microtubule-associated protein-like 2 isoform 4
NM_001352052.1 NP_001338981.1 echinoderm microtubule-associated protein-like 2 isoform 5
NM_001352053.2 NP_001338982.1 echinoderm microtubule-associated protein-like 2 isoform 6
NM_001352054.2 NP_001338983.1 echinoderm microtubule-associated protein-like 2 isoform 7
NM_012155.4 NP_036287.1 echinoderm microtubule-associated protein-like 2 isoform 2

EML2 Protein Structure

HELP

HELP: HELP motif (17 - 94)

WD40

WD40: WD domain, G-beta repeat (99 - 123)

WD40

WD40: WD domain, G-beta repeat (288 - 321)

WD40

WD40: WD domain, G-beta repeat (374 - 405)

WD40

WD40: WD domain, G-beta repeat (454 - 487)

WD40

WD40: WD domain, G-beta repeat (500 - 534)

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  • 649 a.a.
Protein Preferred Names Protein Names

echinoderm microtubule-associated protein-like 2

  • echinoderm MT-associated protein (EMAP)-like protein 70

EML2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
EML2 O95834 EXD1 Homo sapiens Q8NHP7
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Sulfonamide Allergy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04354 EML2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17687 Eml2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24148 Eml2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus EML2 VGNC VGNC:28476
Felis catus EML2 VGNC VGNC:61849
Mus musculus EML2 MGD MGI:1919455
Rattus norvegicus EML2 RGD RGD:621066
Canis familiaris EML2 VGNC VGNC:40347
Others EML2 NCBI