Dyrk3 - dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 Gene

Species: Mus musculus

Gene Type: protein coding
Gene ID: 226419

About Dyrk3

Chromosome 1: 131,055,192-131,066,077 reverse strand.GRCm39:CM000994.3

This gene has 2 transcripts (splice variants), 201 orthologues, 12 paralogues and is associated with 2 phenotypes. Biased expression in testis adult (RPKM 67.2), liver E14.5 (RPKM 1.2) and 7 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including erythrocyte differentiation; negative regulation of DNA damage response, signal transduction by p53 class mediator; and protein phosphorylation. Predicted to be located in several cellular components, including cytoplasmic stress granule; nuclear speck; and pericentriolar material. Predicted to be active in cytoplasm; cytoskeleton; and nucleus. Is expressed in several structures, including alimentary system; hemolymphoid system gland; musculature; nasal cavity epithelium; and reproductive system. Orthologous to human DYRK3 (dual specificity tyrosine phosphorylation regulated kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Dyrk3 Products (1)

mRNA Protein Name
NM_145508.2 NP_663483.1 dual specificity tyrosine-phosphorylation-regulated kinase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables ATP binding IDA
IDA: Inferred from direct assay
12356771 MGI
enables magnesium ion binding IDA
IDA: Inferred from direct assay
12356771 MGI
enables protein binding IPI
IPI: Inferred from physical interaction
20167603 MGI
enables protein kinase activity IDA
IDA: Inferred from direct assay
12356771 MGI
enables protein serine/threonine kinase activity IMP
IMP: Inferred from mutant phenotype
20167603 MGI
Biological Process GO Annotation Evidence Verweise Source
involved in erythrocyte differentiation IDA
IDA: Inferred from direct assay
16524748 MGI
involved in negative regulation of DNA damage response, signal transduction by p53 class mediator IMP
IMP: Inferred from mutant phenotype
20167603 MGI
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20167603 MGI
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
12356771 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Dyrk3 Protein Structure

PKc_DYRK2_3

PKc_DYRK2_3: cd14224 (141 - 520)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 586 a.a.
Protein Preferred Names Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 3

Dyrk3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
Dyrk3 Q922Y0 Sirt1 Mus musculus Q923E4
Protein Kinase Assay
20167603
Intra
Dyrk3 Q922Y0 Sirt1 Mus musculus Q923E4
IF
20167603
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-105309 GSK-626616 Inhibitor 99.88% Unkown
HY-117049 Leucettine L41 Inhibitor 98.98% Unkown
HY-162750 ZJCK-6-46 Inhibitor 99.06% Unkown
HY-402805 DYRK2-IN-2 Inhibitor / Unkown
HY-402805A DYRK2-IN-2 hydrochloride Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dyrk3 NCBI NCBI:8444