DYRK3 - dual specificity tyrosine phosphorylation regulated kinase 3 Gene

Homo sapiens

Also known as RED; REDK; DYRK5; hYAK3-2

Gene ID: 8444 | Gene type: protein coding

About DYRK3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,635,536-206,655,158 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 12 paralogues. Broad expression in testis (RPKM 8.5), gall bladder (RPKM 5.7) and 19 other tissues.

Summary

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

DYRK3 Products(7)

mRNA	Protein	Name
XM_047432114.1	XP_047288070.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
NM_001004023.3	NP_001004023.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b
XM_047432115.1	XP_047288071.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
XM_047432118.1	XP_047288074.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
XM_011510061.3	XP_011508363.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
NM_003582.4	NP_003573.2	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a
XM_005273315.5	XP_005273372.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

DYRK3 Protein Structure

Pkinase

0
100
200
300
400
500
588 a.a.

Protein Preferred Names

Protein Names

dual specificity tyrosine-phosphorylation-regulated kinase 3

dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3	dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5
protein kinase Dyrk3	regulatory erythroid kinase

Recombinant DYRK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76308	DYRK3 Protein, Human (sf9, His-GST)	O43781 (M1-S588)	≥95%

Related Diseases

Diseases

Alias

Neuroaspergillosis

Intellectual Developmental Disorder, Autosomal Dominant 7

MRD7	Mental Retardation, Autosomal Dominant 7
Autosomal Dominant Non-Syndromic Intellectual Disability 7	Dyrk1a Syndrome
Autosomal Dominant Intellectual Developmental Disorder 7	Autosomal Dominant Mental Retardation 7
Mental Retardation, Autosomal Dominant, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-105309	GSK-626616	Inhibitor	99.68%	Phase 1

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-111379	EHT 5372	Inhibitor	98.12%	Unkown
HY-122665	HTH-01-091	Inhibitor	98.64%	Unkown
HY-122665A	HTH-01-091 TFA	Inhibitor	99.48%	Unkown
HY-155723	Leucettinib-92	Inhibitor	/	Unkown
HY-RS04102	Dyrk3 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS04103	Dyrk3 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DYRK3	RGD	RGD:1310924
Canis familiaris	DYRK3	VGNC	VGNC:40158
Mus musculus	DYRK3	MGD	MGI:1330300
Macaca mulatta	DYRK3	VGNC	VGNC:72020
Bos taurus	DYRK3	VGNC	VGNC:28281
Felis catus	DYRK3	VGNC	VGNC:61688
Others	DYRK3	NCBI

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