DYRK3 - dual specificity tyrosine phosphorylation regulated kinase 3 Gene

Also Known as RED; REDK; DYRK5; hYAK3-2

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8444

About DYRK3

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:206,635,536-206,655,158 (from NCBI)

This gene has 6 transcripts (splice variants), 201 orthologues and 12 paralogues. Broad expression in testis (RPKM 8.5), gall bladder (RPKM 5.7) and 19 other tissues.

Summary

This gene product belongs to the DYRK family of dual-specificity protein kinases that catalyze autophosphorylation on serine/threonine and tyrosine residues. The members of this family share structural similarity, however, differ in their substrate specificity, suggesting their involvement in different cellular functions. The encoded protein has been shown to autophosphorylate on tyrosine residue and catalyze phosphorylation of histones H3 and H2B in vitro. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]

DYRK3 Products (7)

mRNA	Protein	Name
XM_047432114.1	XP_047288070.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
NM_001004023.3	NP_001004023.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform b
XM_047432115.1	XP_047288071.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1
XM_047432118.1	XP_047288074.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
XM_011510061.3	XP_011508363.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X2
NM_003582.4	NP_003573.2	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform a
XM_005273315.5	XP_005273372.1	dual specificity tyrosine-phosphorylation-regulated kinase 3 isoform X1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ATP binding	IDA IDA: Inferred from direct assay	10779429	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	10779429	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein kinase activity	IDA IDA: Inferred from direct assay	10779429	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	29634919	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	23415227	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in erythrocyte differentiation	IDA IDA: Inferred from direct assay	10779429	GOA
involved in nuclear speck organization	IDA IDA: Inferred from direct assay	29973724	GOA
involved in organelle disassembly	IDA IDA: Inferred from direct assay	29973724	GOA
involved in positive regulation of cell cycle G2/M phase transition	IDA IDA: Inferred from direct assay	29973724	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	10779429	GOA
involved in regulation of TORC1 signaling	IMP IMP: Inferred from mutant phenotype	23415227	GOA
involved in regulation of cellular response to stress	IMP IMP: Inferred from mutant phenotype	23415227	GOA
involved in stress granule disassembly	IDA IDA: Inferred from direct assay	29973724	GOA
involved in stress granule disassembly	IMP IMP: Inferred from mutant phenotype	23415227	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23415227	GOA
located in cytoplasmic stress granule	IDA IDA: Inferred from direct assay	23415227	GOA
located in nuclear speck	IDA IDA: Inferred from direct assay	29973724	GOA
located in nucleus	IDA IDA: Inferred from direct assay	10779429	GOA
located in pericentriolar material	IDA IDA: Inferred from direct assay	29973724	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DYRK3 Protein Structure

Pkinase

0
100
200
300
400
500
588 a.a.

Protein Preferred Names	Protein Names
dual specificity tyrosine-phosphorylation-regulated kinase 3	dual specificity tyrosine-(Y)-phosphorylation regulated kinase 3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 5 protein kinase Dyrk3 regulatory erythroid kinase

Recombinant DYRK3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76308	DYRK3 Protein, Human (Active, sf9, His-GST)	O43781 (M1-S588)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Neuroaspergillosis
Intellectual Developmental Disorder, Autosomal Dominant 7	MRD7 Mental Retardation, Autosomal Dominant 7 Autosomal Dominant Non-Syndromic Intellectual Disability 7 Dyrk1a Syndrome Autosomal Dominant Intellectual Developmental Disorder 7 Autosomal Dominant Mental Retardation 7 Mental Retardation, Autosomal Dominant, Type 7

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-105309	GSK-626616	Inhibitor	99.88%	Unkown
HY-117049	Leucettine L41	Inhibitor	98.98%	Unkown
HY-162750	ZJCK-6-46	Inhibitor	99.06%	Unkown
HY-402805	DYRK2-IN-2	Inhibitor	/	Unkown
HY-402805A	DYRK2-IN-2 hydrochloride	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	DYRK3	RGD	RGD:1310924
Canis familiaris	DYRK3	VGNC	VGNC:40158
Mus musculus	DYRK3	MGD	MGI:1330300
Macaca mulatta	DYRK3	VGNC	VGNC:72020
Bos taurus	DYRK3	VGNC	VGNC:28281
Felis catus	DYRK3	VGNC	VGNC:61688
Others	DYRK3	NCBI