PTGR1 - prostaglandin reductase 1 Gene

Also Known as PGR1; DIG-1; ZADH3; LTB4DH

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 22949

About PTGR1

Cytogenetic location: 9q31.3 Genomic coordinates (GRCh38): 9:111,549,722-111,599,647 (from NCBI)

This gene has 9 transcripts (splice variants), 283 orthologues and 17 paralogues. Broad expression in liver (RPKM 118.8), small intestine (RPKM 109.3) and 18 other tissues.

Summary

This gene encodes an enzyme that is involved in the inactivation of the chemotactic factor, leukotriene B4. The encoded protein specifically catalyzes the NADP+ dependent conversion of leukotriene B4 to 12-oxo-leukotriene B4. A pseudogene of this gene is found on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]

PTGR1 Products (3)

mRNA Protein Name
NM_001146108.2 NP_001139580.1 prostaglandin reductase 1 isoform 1
NM_001146109.2 NP_001139581.1 prostaglandin reductase 1 isoform 2
NM_012212.3 NP_036344.2 prostaglandin reductase 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables 15-oxoprostaglandin 13-oxidase [NAD(P)+] activity IDA
IDA: Inferred from direct assay
25619643 GOA
enables 2-alkenal reductase (NADPH) activity IDA
IDA: Inferred from direct assay
25619643 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32814053 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in prostaglandin metabolic process IDA
IDA: Inferred from direct assay
25619643 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PTGR1 Protein Structure

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (153 - 287)

  • 0
  • 100
  • 200
  • 300
  • 329 a.a.
Protein Preferred Names Protein Names

prostaglandin reductase 1

  • 15-oxoprostaglandin 13-reductase

PTGR1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PTGR1 Q14914 JPH3 Homo sapiens Q8WXH2
Validated Y2H
32814053
Intra
PTGR1 Q14914 JPH3 Homo sapiens Q8WXH2
Y2H Array
32814053
Intra
PTGR1 Q14914 JPH3 Homo sapiens Q8WXH2
Y2H Pooling
32814053
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS11390 PTGR1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20089 Ptgr1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26592 Ptgr1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris PTGR1 VGNC VGNC:45150
Mus musculus PTGR1 MGD MGI:1914353
Bos taurus PTGR1 VGNC VGNC:33510
Rattus norvegicus PTGR1 RGD RGD:621195
Felis catus PTGR1 VGNC VGNC:97574
Others PTGR1 NCBI