Lrrk1 - leucine-rich repeat kinase 1 Gene

Also Known as mKIAA1790; C230002E15Rik; D130026O16Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 233328

Summary

Predicted to enable identical protein binding activity and protein kinase activity. Acts upstream of or within several processes, including bone resorption; osteoclast development; and regulation of peptidyl-tyrosine phosphorylation. Predicted to be located in cytosol and mitochondrion. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Used to study osteopetrosis. Orthologous to human LRRK1 (leucine rich repeat kinase 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrrk1 Products (1)

mRNA Protein Name
NM_146191.3 NP_666303.3 leucine-rich repeat serine/threonine-protein kinase 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
23526378 MGI
Biological Process GO Annotation Evidence Verweise Source
acts upstream of or within bone resorption IMP
IMP: Inferred from mutant phenotype
23526378 MGI
acts upstream of intracellular signal transduction IGI
IGI: Inferred from genetic interaction
23526378 MGI
acts upstream of or within negative regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
23526378 MGI
acts upstream of or within osteoclast development IGI
IGI: Inferred from genetic interaction
23526378 MGI
acts upstream of or within osteoclast development IMP
IMP: Inferred from mutant phenotype
23526378 MGI
acts upstream of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
23526378 MGI
acts upstream of or within positive regulation of intracellular signal transduction IGI
IGI: Inferred from genetic interaction
23526378 MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation IMP
IMP: Inferred from mutant phenotype
23526378 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

leucine-rich repeat serine/threonine-protein kinase 1

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-174420 RN277 Inhibitor / Unkown
HY-W107722 IN04 98.51% Unkown
HY-RS07832 LRRK1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20443 Lrrk1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26952 Lrrk1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Lrrk1 NCBI NCBI:79705