CLDN15 - claudin 15 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 24146

About CLDN15

Cytogenetic location: 7q22.1 Genomic coordinates (GRCh38): 7:101,232,094-101,238,820 (from NCBI)

This gene has 8 transcripts (splice variants), 200 orthologues and 22 paralogues. Biased expression in duodenum (RPKM 65.8), small intestine (RPKM 50.2) and 8 other tissues.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jun 2010]

CLDN15 Products (2)

mRNA Protein Name
NM_001185080.2 NP_001172009.1 claudin-15
NM_014343.3 NP_055158.1 claudin-15

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables paracellular tight junction channel activity IDA
IDA: Inferred from direct assay
31188544 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in paracellular transport IDA
IDA: Inferred from direct assay
31188544 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in tight junction IDA
IDA: Inferred from direct assay
31188544 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN15 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (8 - 177)

  • 0
  • 100
  • 200
  • 228 a.a.
Protein Preferred Names Protein Names

claudin-15

Related Diseases

Diseases Alias
Collagenous Colitis

  • Colitis, Collagenous

  • Microscopic Colitis, Collagenous Type
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS02766 CLDN15 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta CLDN15 VGNC VGNC:80863
Mus musculus CLDN15 MGD MGI:1913103
Bos taurus CLDN15 VGNC VGNC:27405
Rattus norvegicus CLDN15 RGD RGD:1310678
Felis catus CLDN15 VGNC VGNC:80559
Others CLDN15 NCBI