PLAAT1 - phospholipase A and acyltransferase 1 Gene

Also Known as A-C1; HRSL1; HSD28; HRASLS; HRASLS1; PLA/AT1; PLAAT-1; H-REV107

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57110

About PLAAT1

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:193,240,606-193,281,426 (from NCBI)

This gene has 3 transcripts (splice variants), 273 orthologues and 7 paralogues. Biased expression in testis (RPKM 17.3), thyroid (RPKM 1.8) and 3 other tissues.

Summary

Enables Acyltransferase activity, transferring groups Other than amino-acyl groups and Phospholipase activity. Involved in N-acylphosphatidylethanolamine metabolic process and phosphatidylcholine metabolic process. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

PLAAT1 Products (2)

mRNA Protein Name
NM_001366112.1 NP_001353041.1 phospholipase A and acyltransferase 1
NM_020386.5 NP_065119.3 phospholipase A and acyltransferase 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables N-acyltransferase activity IDA
IDA: Inferred from direct assay
21880860 GOA
enables O-acyltransferase activity IDA
IDA: Inferred from direct assay
21880860 GOA
enables phospholipase A1 activity IDA
IDA: Inferred from direct assay
21880860 GOA
enables phospholipase A2 activity IDA
IDA: Inferred from direct assay
21880860 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in N-acylphosphatidylethanolamine metabolic process IDA
IDA: Inferred from direct assay
22825852 GOA
involved in phosphatidylcholine metabolic process IDA
IDA: Inferred from direct assay
21880860 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
27623847 GOA
located in nucleus IDA
IDA: Inferred from direct assay
27623847 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLAAT1 Protein Structure

LRAT

LRAT: Lecithin retinol acyltransferase (15 - 131)

  • 0
  • 100
  • 168 a.a.
Protein Preferred Names Protein Names

phospholipase A and acyltransferase 1

  • H-REV107 protein-related protein

PLAAT1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
PLAAT1 Q9HDD0 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
PLAAT1 Q9HDD0 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
PLAAT1 Q9HDD0 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Bothnia Retinal Dystrophy

  • Vasterbotten Dystrophy

  • BRD

  • Dystrophy, Retinal, Bothnia
Poland Syndrome

  • Poland Anomaly

  • Poland Sequence

  • Poland Syndactyly

  • Poland'S Syndrome

  • Poland'S Anomaly

  • Poland'S Syndactyly

  • Acro-Pectoro-Renal Field Defect

  • Brachydactyly, Absent Pectoral Muscles And Agenesis/Hypoplasia Of Kidneys

  • Unilateral Defect Of Pectoralis Muscle And Syndactyly Of The Hand

  • Unilateral Defect Of Pectoralis Major And Syndactyly Of The Hand
Microphthalmia, Syndromic 9

  • Matthew-Wood Syndrome

  • Spear Syndrome

  • Anophthalmia/Microphthalmia And Pulmonary Hypoplasia

  • Microphthalmia, Isolated, With Coloboma 8

  • MCOPS9

  • Anophthalmia, Clinical, With Mild Facial Dysmorphism And Variable Malformations Of The Lung, Heart, And Diaphragm

  • Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect

  • Pdac

  • Pulmonary Agenesis, Microphthalmia, And Diaphragmatic Defect

  • Pmd

  • Syndromic Microphthalmia 9

  • Anophthalmia-Pulmonary Hypoplasia Syndrome

  • Clinical Anophthalmia Mild Facial Dysmorphism Lung Heart And Diaphragm Malformations

  • Pulmonary Agenesis Microphthalmi And Diaphragmatic Defect

  • Microphthalmia Syndromic 9

  • Matthew Wood Syndrome

  • Pdac Syndrome

  • Pulmonary Hypoplasia-Diaphragmatic Hernia-Anophthalmia-Cardiac Defect Syndrome

  • Microphthalmia, Isolated, With Coloboma, 8

  • MCOPCB8

  • Isolated Colobomatous Microphthalmia 8

  • Microphthalmia, Syndromic, 9

  • Anophthalmia With Pulmonary Hypoplasia

  • Microphthalmia Syndromic, Type 9

  • Anophthalmia And Pulmonary Hypoplasia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10637 PLAAT1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus PLAAT1 VGNC VGNC:102805
Bos taurus PLAAT1 VGNC VGNC:53580
Macaca mulatta PLAAT1 VGNC VGNC:76029
Canis familiaris PLAAT1 VGNC VGNC:41782
Rattus norvegicus PLAAT1 RGD RGD:1309485
Mus musculus PLAAT1 MGD MGI:1351473
Others PLAAT1 NCBI