STC1 - stanniocalcin 1 Gene

Also Known as STC

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6781

About STC1

Cytogenetic location: 8p21.2 Genomic coordinates (GRCh38): 8:23,841,929-23,854,806 (from NCBI)

This gene has 2 transcripts (splice variants), 277 orthologues and 1 paralogue. Broad expression in endometrium (RPKM 33.6), thyroid (RPKM 19.7) and 14 other tissues.

Summary

This gene encodes a secreted, homodimeric glycoprotein that is expressed in a wide variety of tissues and may have autocrine or paracrine functions. The gene contains a 5' UTR rich in CAG trinucleotide repeats. The encoded protein contains 11 conserved cysteine residues and is phosphorylated by protein kinase C exclusively on its serine residues. The protein may play a role in the regulation of renal and intestinal calcium and phosphate transport, cell metabolism, or cellular calcium/phosphate homeostasis. Overexpression of human stanniocalcin 1 in mice produces high serum phosphate levels, dwarfism, and increased metabolic rate. This gene has altered expression in hepatocellular, ovarian, and breast cancers. [provided by RefSeq, Jul 2008]

STC1 Products (1)

mRNA Protein Name
NM_003155.3 NP_003146.1 stanniocalcin-1 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
26195635 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in bone development IDA
IDA: Inferred from direct assay
16377640 GOA
involved in chondrocyte proliferation IDA
IDA: Inferred from direct assay
16377640 GOA
involved in endothelial cell morphogenesis IDA
IDA: Inferred from direct assay
14500721 GOA
involved in growth plate cartilage axis specification IDA
IDA: Inferred from direct assay
16377640 GOA
involved in intracellular calcium ion homeostasis IDA
IDA: Inferred from direct assay
8700837 GOA
involved in negative regulation of calcium ion transport IDA
IDA: Inferred from direct assay
8700837 GOA
acts upstream of positive effect negative regulation of cell migration IDA
IDA: Inferred from direct assay
17032941 GOA
involved in negative regulation of endothelial cell migration IDA
IDA: Inferred from direct assay
14500721 GOA
involved in negative regulation of renal phosphate excretion IDA
IDA: Inferred from direct assay
8700837 GOA
involved in positive regulation of calcium ion import IDA
IDA: Inferred from direct assay
17032941 GOA
involved in regulation of cardiac muscle cell contraction IDA
IDA: Inferred from direct assay
12663264 GOA
involved in regulation of monoatomic anion transport IDA
IDA: Inferred from direct assay
16377640 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12663264 GOA
located in nucleus IDA
IDA: Inferred from direct assay
12663264 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

STC1 Protein Structure

Stanniocalcin

Stanniocalcin: Stanniocalcin family (1 - 208)

  • 0
  • 100
  • 200
  • 247 a.a.
Protein Preferred Names Protein Names

stanniocalcin-1

STC1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
STC1 P52823 STC1 Homo sapiens P52823
Comig Non-Denat Gel
26195635
Intra
STC1 P52823 PAPPA Homo sapiens Q13219
SPR
26195635
Intra
STC1 P52823 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
STC1 P52823 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
STC1 P52823 STC1 Homo sapiens P52823
GMS
26195635
Intra
STC1 P52823 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant STC1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P71338 STC1/Stanniocalcin-1 Protein, Human (HEK293, His) P52823-1 (T18-A247) ≥ 95%, as determined by reducing SDS-PAGE.

STC1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P810764 Stanniocalcin 1 Antibody (YA10007) WB, ICC/IF, IP Human
HY-P82945 Stanniocalcin 1 Antibody (YA2690) WB, IP Human

Related Diseases

Diseases Alias
Fibrosarcoma

  • Neoplasms, Fibrous Tissue

  • Fibrocytic Tumor

  • Fibrosarcoma Of Soft Tissue

  • Fibrous Tissue Neoplasm
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS16228 Stc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS13903 STC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23646 Stc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris STC1 VGNC VGNC:46895
Bos taurus STC1 VGNC VGNC:35377
Felis catus STC1 VGNC VGNC:65767
Rattus norvegicus STC1 RGD RGD:621776
Macaca mulatta STC1 VGNC VGNC:84120
Mus musculus STC1 MGD MGI:109131
Others STC1 NCBI