ADAM33 - ADAM metallopeptidase domain 33 Gene

Also Known as C20orf153; DJ964F7.1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 80332

About ADAM33

Cytogenetic location: 20p13 Genomic coordinates (GRCh38): 20:3,667,975-3,682,010 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 20 paralogues. Broad expression in endometrium (RPKM 33.9), gall bladder (RPKM 16.7) and 17 other tissues.

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This protein is a type I transmembrane protein implicated in asthma and bronchial hyperresponsiveness. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]

ADAM33 Products (3)

mRNA Protein Name
NM_001282447.3 NP_001269376.1 disintegrin and metalloproteinase domain-containing protein 33 isoform gamma precursor
NM_025220.5 NP_079496.1 disintegrin and metalloproteinase domain-containing protein 33 isoform alpha preproprotein
NM_153202.4 NP_694882.1 disintegrin and metalloproteinase domain-containing protein 33 isoform beta precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ADAM33 Protein Structure

Pep_M12B_propep

Pep_M12B_propep: Reprolysin family propeptide (39 - 165)

Reprolysin

Reprolysin: Reprolysin (M12B) family zinc metalloprotease (210 - 409)

Disintegrin

Disintegrin: Disintegrin (426 - 500)

ADAM_CR

ADAM_CR: ADAM cysteine-rich (503 - 611)

  • 0
  • 200
  • 400
  • 600
  • 813 a.a.
Protein Preferred Names Protein Names

disintegrin and metalloproteinase domain-containing protein 33

  • ADAM 33

Related Diseases

Diseases Alias
Childhood-Onset Asthma

  • Childhood Asthma

  • Asthma Childhood
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Allergic Asthma

  • Atopic Asthma

  • Extrinsic Asthma

  • Extrinsic Asthma With Acute Exacerbation

  • Extrinsic Asthma With Status Asthmaticus

  • Asthma Allergic

  • Atopic Asthma, Susceptibility To

  • Ige-Mediated Allergic Asthma

  • Allergen-Induced Asthma

  • Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma Without Stated Status Asthmaticus

  • Predominantly Allergic Asthma

  • Allergic Asthma Nos

  • Catarrh With Asthma

  • Allergic Bronchitis Nos

  • Extrinsic Allergic Asthma

  • Predominantly Allergic Asthma With Stated Status Asthmaticus
Pulmonary Disease, Chronic Obstructive

  • Chronic Obstructive Pulmonary Disease

  • COPD

  • Pulmonary Disease, Chronic Obstructive, Severe Early-Onset

  • Chronic Obstructive Lung Disease

  • Chronic Obstructive Airway Disease

  • Pulmonary Disease, Chronic Obstructive, Susceptibility To

  • Cold

  • Severe Early-Onset Chronic Obstructive Pulmonary Disease

  • Pulmonary Disease Chronic Obstructive

  • Pulmonary Disease, Obstructive, Chronic, Susceptibility To

  • Chronic Obstructive Pulmonary Disease Of Horses

  • Common Cold

  • Upper Respiratory Infections

  • Copd - [Chronic Obstructive Pulmonary Disease]

  • Coad - [Chronic Obstructive Airways Disease]

  • Cold - [Chronic Obstructive Lung Disease]

  • Chronic Airway Disease Nos

  • Chronic Airways Limitation, Unspecified

  • Chronic Obstructed Airway, Unspecified

  • Chronic Obstructive Airway Disease, Unspecified

  • Chronic Obstructive Airway, Unspecified

  • Obstructive Lung Disease Nos

  • Chronic Obstructive Lung Disease Nos

  • Chronic Obstructive Lung Nos

  • Obstructive Pulmonary Disease Nos

  • Exacerbation Copd Nos

  • Acute Exacerbation Copd
Near-Fatal Asthma
Occupational Asthma
Environmental Induced Asthma

  • Irritant Asthma
Intrinsic Asthma

  • Non-Atopic Asthma
Chronic Asthma
Bronchial Disease

  • Bronchial Diseases

  • Bronchial Disorders

  • Bronchial Spasm
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS00284 ADAM33 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20134 Adam33 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26637 Adam33 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus ADAM33 VGNC VGNC:59583
Rattus norvegicus ADAM33 RGD RGD:1305278
Macaca mulatta ADAM33 VGNC VGNC:69409
Canis familiaris ADAM33 VGNC VGNC:37585
Mus musculus ADAM33 MGD MGI:1341813
Bos taurus ADAM33 VGNC VGNC:25611
Others ADAM33 NCBI