FBXL20 - F-box and leucine rich repeat protein 20 Gene

Also Known as Fbl2; Fbl20

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84961

About FBXL20

Cytogenetic location: 17q12 Genomic coordinates (GRCh38): 17:39,252,663-39,402,556 (from NCBI)

This gene has 6 transcripts (splice variants), 241 orthologues and 15 paralogues. Ubiquitous expression in testis (RPKM 3.5), brain (RPKM 3.2) and 25 other tissues.

Summary

Members of the F-box protein family, such as FBXL20, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through Other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]

FBXL20 Products (4)

mRNA Protein Name
NM_001184906.2 NP_001171835.1 F-box/LRR-repeat protein 20 isoform 2
NM_001370208.3 NP_001357137.2 F-box/LRR-repeat protein 20 isoform 3
NM_001370209.3 NP_001357138.2 F-box/LRR-repeat protein 20 isoform 4
NM_032875.3 NP_116264.2 F-box/LRR-repeat protein 20 isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
27705803 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FBXL20 Protein Structure

F-box-like

F-box-like: F-box-like (27 - 70)

LRR_6

LRR_6: Leucine Rich repeat (116 - 133)

LRR_6

LRR_6: Leucine Rich repeat (142 - 165)

LRR_6

LRR_6: Leucine Rich repeat (168 - 190)

LRR_6

LRR_6: Leucine Rich repeat (220 - 243)

LRR_6

LRR_6: Leucine Rich repeat (246 - 270)

LRR_6

LRR_6: Leucine Rich repeat (324 - 348)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 436 a.a.
Protein Preferred Names Protein Names

F-box/LRR-repeat protein 20

  • F-box protein FBL2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS04790 FBXL20 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FBXL20 RGD RGD:621722
Felis catus FBXL20 VGNC VGNC:97433
Bos taurus FBXL20 VGNC VGNC:52776
Mus musculus FBXL20 MGD MGI:1919444
Canis familiaris FBXL20 VGNC VGNC:54947
Macaca mulatta FBXL20 VGNC VGNC:81407
Others FBXL20 NCBI