DIRAS3 - DIRAS family GTPase 3 Gene

Also Known as ARHI; NOEY2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9077

About DIRAS3

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:68,045,962-68,050,627 (from NCBI)

This gene has 4 transcripts (splice variants), 50 orthologues and 35 paralogues. Biased expression in ovary (RPKM 20.7), adrenal (RPKM 6.9) and 11 other tissues.

Summary

This gene encodes a member of the Ras superfamily. This gene is imprinted gene with monoallelic expression of the paternal allele which is associated with growth suppression. The encoded protein acts as a tumor suppressor whose function is abrogated in many ovarian and breast cancers. This protein may also play a role Autophagy in certain Cancer cells by regulating the autophagosome initiation complex. [provided by RefSeq, Nov 2015]

DIRAS3 Products (1)

mRNA Protein Name
NM_004675.5 NP_004666.1 GTP-binding protein Di-Ras3 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21643014 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

DIRAS3 Protein Structure

Ras

Ras: Ras family (39 - 197)

  • 0
  • 100
  • 200
  • 229 a.a.
Protein Preferred Names Protein Names

GTP-binding protein Di-Ras3

  • DIRAS family, GTP-binding RAS-like 3

DIRAS3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
DIRAS3 O95661 MEOX2 Homo sapiens Q6FHY5
Validated Y2H
32296183
Intra
DIRAS3 O95661 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
DIRAS3 O95661 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
DIRAS3 O95661 STAT3 Homo sapiens P40763
Anti Bait CoIP
21643014
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant DIRAS3 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P75500 ARHI Protein, Human (HEK293, Fc) O95661 (M1-K225) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Transient Neonatal Diabetes Mellitus

  • Diabetes Mellitus, Transient Neonatal

  • Tndm

  • Chromosome 6-Associated Transient Diabetes Mellitus

  • Dmtn

  • Diabetes Mellitus, 6q24-Related Transient Neonatal

  • Tndm1

  • Neonatal Diabetes Mellitus, Transient

  • Tndm -[Transient Neonatal Diabetes Mellitus]
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Beckwith-Wiedemann Syndrome

  • Wiedemann-Beckwith Syndrome

  • BWS

  • Exomphalos-Macroglossia-Gigantism Syndrome

  • Emg Syndrome

  • Beckwith-Wiedemann Syndrome Due To Cdkn1c Mutation

  • Emg Abnormality

  • Wbs

  • Exomphalos Macroglossia Gigantism Syndrome

  • Beckwith-Wiedemann Syndrome Due To Nsd1 Mutation

  • Macroglossia Exomphalos Gigantism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS03777 DIRAS3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus DIRAS3 VGNC VGNC:28071
Macaca mulatta DIRAS3 VGNC VGNC:71827
Rattus norvegicus DIRAS3 RGD RGD:1565168
Others DIRAS3 NCBI