IACS-56676
IACS-56676 is a selective NRASG12D inhibitor with a target IC50 of 0.031 μM. IACS-56676 stabilizes the p-loop, maintains key interactions with Asp12, Gly60 and Asp69, and achieves selectivity against wild-type KRAS through substitution targeting Leu95. IACS-56676 can be used in the research of melanoma, hematologic malignancies and thyroid cancer.
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- CAS. Nr.: 3105153-34-9
- Formel: C28H28ClF4N5O
- Molecular Weight:562.00
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biologische Aktivität
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Chemical Information
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
Biologische Aktivität
IACS-56676 potently reduces viability of NRASG12D-mutant THP1 cells with an IC50 of 0.073 μM[1].
IACS-56676 has minimal CYP inhibition activity, with no measurable inhibition of CYP2D6 and CYP2C9 up to 10 μM, and weak inhibition of CYP3A4 isoforms[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 3105153-34-9
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Molecular Weight 562.00
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Formel C28H28ClF4N5O
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SMILES
NC1=CC(C2=C(F)C(N(C3CC3)C(CNC(C)=O)=C4[C@@]5([H])[C@@]6([H])[C@]5([H])CNC6)=C4C(C7CC7)=N2)=C(C(F)(F)F)C(Cl)=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
IACS-56676 Related Classifications
HY-181555 Related Classifications
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