Cytotoxic neoclerodane diterpenoids from Scutellaria barbata

  • J Nat Prod. 2010 Feb 26;73(2):233-6. doi: 10.1021/np900309p.
Feng Zhu  1 ,  Ying-Tong Di ,  Ling-Li Liu ,  Qiang Zhang ,  Xin Fang ,  Ting-Quan Yang ,  Xiao-Jiang Hao ,  Hong-Ping He
Affiliations
  • 1. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, Yunnan, People's Republic of China.
PMID: 20078074 DOI: 10.1021/np900309p
Abstract

Seven new neoclerodane Diterpenoids, scutebatas A-G (1-7), have been isolated from Scutellaria barbata. Compounds 1-3 possess a rare alpha-hydroxy group in their alpha,beta-unsaturated lactone rings. Their structures were elucidated by spectroscopic analysis, and the relative configuration of scutebata A was deduced using ROESY data and the computational DFT method. Compounds 1, 2, 4, 5, and 6 were evaluated for in vitro cytotoxicity against six human Cancer cell lines: HL-60, SMMC-7721, A-549, SK-BR-3, CACO-2, and PANC-1. Scutebata A (1) showed weak cytotoxicity against SK-BR-3 with an IC(50) value of 15.2 muM.

Products