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2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt

(Synonyms: ADU-S100 ammonium salt; MIW815 ammonium salt; ML RR-S2 CDA ammonium salt)
90 Cited Publications
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Based on 90 publication(s) in Google Scholar

2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt (ADU-S100 ammonium salt), an activator of stimulator of interferon genes (STING), leads to potent and systemic tumor regression and immunity.

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  • Purity: 99.60%
  • CAS No.: 1638750-96-5
  • Formula: C20H30N12O10P2S2
  • Molecular Weight:724.60
  • Storage:

    -20°C, sealed storage, away from moisture and light

    * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

  • 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Chemical Structure
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Chemical Structure
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Chemical Structure
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
  • Experimental Validation Results for 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt
CAS No.: 1638750-96-5
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  • 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Chemical Structure
    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt Chemical Structure
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    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1766-1780. [Abstract]

    Customer Validation
     2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100) (10 μM) was added to the culture of KPC cells or endothelial cells (HUVEC) for indicated time, and the activation of STING signaling was analyzed by IRF3 Ser385 phosphorylation. The quantification of phosphorylated IRF3 was normalized by total IRF3. β-actin was used as a loading control.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1766-1780. [Abstract]

    Customer Validation
     Leukocytes were isolated from peripheral blood or the peritoneum of normal mice and incubated in vitro with 7.2  μg/mL STING agonist 2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100) for 2 h at 37 °C. Phosphorylation of IRF3 in leukocyte subsets (CD11b+ myeloid cells, CD3+ cells, CD19+ cells, and NK1.1+ cells) was detected by α-phospho-IRF3 Ser385 antibody staining. Cells were permeabilized using eBioscience™ Transcription Factor Staining Buffer Set before staining. The percent fraction of phospho-IRF3+ cells in each subset of blood or peritoneal leukocytes was determined by flow cytometry.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Nat Immunol. 2025 Oct;26(10):1766-1780. [Abstract]

    Customer Validation
     STING agonist 2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100) (2 μg intratumoral) and/or anti-LTβR agonistic antibody (100 μg, intraperitoneal (i.p.)) were administered to mice bearing subcutaneous KPC tumors as monotherapy or in combination as indicated. Immunohistochemistry of B cells (CD19, brown) and HEVs (MECA-79, magenta) shows numerous TLS induced by combination therapy (day 14). Scale bars, 1 mm (low magnification) and 100 μm (high magnification).

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Adv Sci (Weinh). 2025 Apr;12(16):e2414110. [Abstract]

    Customer Validation
     The relative mRNA expression of Ifnβ1 in 4T1 cells, MC38 cells and B16F10 cells after treatment with TACTIC, CS or ADU‐S100 (2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt, 20 µg/mL; 24 h) (n = 3).

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Sep 22:S1525-0016(25)00761-0. [Abstract]

    Customer Validation
     Titration of the agonist ADU-S100 in B16-OVA tumor model. OVA mRNA, 10 μg; C1, 1.6 mg; ADU-S100 (2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt): 10/20/40 μg. n=5 mice per group. The results indicated that the ADU-S100 dosage used (20 μg/mice) was likely optimal for the C1-mRNA+ADU-S100(nano) cancer vaccine.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Sep 22:S1525-0016(25)00761-0. [Abstract]

    Customer Validation
     Representative images of tumor-infiltrating CD8+ T cells by immunohistochemistry (left) and quantification of CD8+ T cells (right). Scale bars: 100 μm (upper) and 50 μm (lower). Tumor-infiltrating immune cell analysis by immunohistochemistry demonstrated that CD8+ T cells were enriched in tumors from Stingf/f Itgax-Cre– mice immunized with C1-OVA mRNA+ADU-S100(nano), but not in tumors from Stingf/f Itgax-Cre+ mice. The doses of mRNA vaccine per mouse in vivo were as follows: mRNA, 10 μg; C1, 1.6 mg; ADU-S100, 20 μg; c-di-AMP, 20 μg. C1-mRNA + ADU-S100(nano) was prepared by encapsulating ADU-S100 into the C1-mRNA nanovaccine during nanoparticle preparation.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 May 13;42(5):850-868.e9. [Abstract]

    Customer Validation
     Cell viability assays of isogenic NTC, Trp53 KO, and Bak/Bax KO Eμ-Myc lymphoma cell lines treated with S63845 in combination with ADU-S100 (2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt, 2-10 μg/mL), MSA-2 (12-34 μM), or diABZI for 24 h.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 May 13;42(5):850-868.e9. [Abstract]

    Customer Validation
     RT-qPCR for BH3-only and STING target genes in three independent isogenic NTC and Trp53 KO Em-Myc lymphoma cell lines treated with ADU-S100 (2’3’-c-di-AM(PS)2 (Rp,Rp) disodium salt, 10 μg/mL) for 24 h.Fold change is relative to the AH15A DMSO-treated NTC sample

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Cancer Cell. 2024 May 13;42(5):850-868.e9. [Abstract]

    Customer Validation
     Cell viability assays of Eμ-Myc lymphoma cell lines treated with ADU-S100 (HY-12885A; AH15A/560: 0.5 μg/mL; 47A: 5 μg/mL) and/or TPCA-1 (HY-10074) for 24 h. Error bars represent SD for three independent experiments. Diagram illustrates how TPCA-1 acts to inhibit NF-κB signaling.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Nat Cell Biol. 2024 Sep;26(9):1585-1596. [Abstract]

    Customer Validation
     Cell viability assays measuring 5-FU response in cGAS knockdown HCT116 cells stably expressing shRNA-resistant cGAS-S213D mutants or pretreated with 10 µM 2’3’-c-di-AM(PS)2 (Rp,Rp) (ADU-S100) for 6 hours.

  • 1/16

    2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt purchased from MedChemExpress. Usage Cited in: Nat Commun. 2023 Mar 13;14(1):1390. [Abstract]

    Customer Validation
     ADU-S100 (10 μM; 48 h; labeled as STING) enhances type I interferon gene expression in human dendritic cells (DCs).

  • 2’3’-c-di-AM(PS)2 (Rp,Rp) ammonium salt