RNMT - RNA guanine-7 methyltransferase Gene

Also Known as MET; Met; CMT1; cm1p; hMet; CMT1c; hCMT1; RG7MT1; N7-MTase

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 8731

About RNMT

Cytogenetic location: 18p11.21 Genomic coordinates (GRCh38): 18:13,726,673-13,764,556 (from NCBI)

This gene has 10 transcripts (splice variants) and 212 orthologues. Ubiquitous expression in brain (RPKM 9.8), thyroid (RPKM 9.0) and 25 other tissues.

Summary

Enables RNA binding activity and mRNA (guanine-N7-)-methyltransferase activity. Involved in 7-methylguanosine mRNA capping. Located in fibrillar center and nucleoplasm. Part of mRNA cap binding activity complex; mRNA cap methyltransferase complex; and receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

RNMT Products (5)

mRNA Protein Name
NM_001308263.2 NP_001295192.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378132.1 NP_001365061.1 mRNA cap guanine-N7 methyltransferase isoform 3
NM_001378134.1 NP_001365063.1 mRNA cap guanine-N7 methyltransferase isoform 1
NM_001378135.1 NP_001365064.1 mRNA cap guanine-N7 methyltransferase isoform 2
NM_003799.3 NP_003790.1 mRNA cap guanine-N7 methyltransferase isoform 2
Molecular Function GO Annotation Evidence References Source
enables RNA binding IMP
IMP: Inferred from mutant phenotype
9790902 GOA
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IDA
IDA: Inferred from direct assay
22099306 GOA
enables mRNA 5'-cap (guanine-N7-)-methyltransferase activity IMP
IMP: Inferred from mutant phenotype
9790902 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
22099306 GOA
Biological Process GO Annotation Evidence References Source
involved in 7-methylguanosine mRNA capping IDA
IDA: Inferred from direct assay
27422871 GOA
involved in 7-methylguanosine mRNA capping IMP
IMP: Inferred from mutant phenotype
9790902 GOA
Cellular Component GO Annotation Evidence References Source
part of mRNA cap methyltransferase RNMT:RAMAC complex IDA
IDA: Inferred from direct assay
22099306 GOA
part of mRNA capping enzyme complex IDA
IDA: Inferred from direct assay
27422871 GOA
located in nucleus IDA
IDA: Inferred from direct assay
9790902 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RNMT Protein Structure

Pox_MCEL

Pox_MCEL: mRNA capping enzyme (137 - 475)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

mRNA cap guanine-N7 methyltransferase

  • RNA (guanine-7-) methyltransferase

RNMT Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20 32296183
Intra
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20 32296183
Intra
RNMT O43148 PLEKHA3 Homo sapiens Q9HB20 32296183
Intra
RNMT O43148 GMCL1 Homo sapiens Q96IK5 32296183
Intra
RNMT O43148 GMCL1 Homo sapiens Q96IK5 32296183
Intra
RNMT O43148 GMCL1 Homo sapiens Q96IK5 32296183
Intra
RNMT O43148 KPNA2 Homo sapiens P52292 32296183
Intra
RNMT O43148 KPNA2 Homo sapiens P52292 32296183
Intra
RNMT O43148 KPNA2 Homo sapiens P52292 32296183
Intra
RNMT O43148 KPNA6 Homo sapiens O60684 33961781
Intra
RNMT O43148 KPNA6 Homo sapiens O60684 32296183
Intra
RNMT O43148 KPNA6 Homo sapiens O60684 32296183
Intra
RNMT O43148 KPNA6 Homo sapiens O60684 32296183
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3 30021884
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3 32296183
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3 32296183
Intra
RNMT O43148 RAMAC Homo sapiens Q9BTL3 32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Microphthalmia, Isolated 6
  • Isolated Microphthalmia 6

  • MCOP6

  • Microphthalmia, Posterior Nonsyndromic

  • Posterior Nonsyndromic Microphthalmia

  • Microphthalmia, Isolated, 6

  • Autosomal Recessive Posterior Microphthalmos

  • Posterior Non-Syndromic Microphthalmia

  • Microphthalmia, Isolated, Type 6

Cardiomyopathy, Familial Restrictive, 1
  • RCM1

  • Restrictive Cardiomyopathy 1

  • Rcm

  • Familial Restrictive Cardiomyopathy 1

  • Cardiomyopathy, Familial Restrictive 1

  • Cardiomyopathy, Restrictive, Familial, Type 1

  • Rcm-1

Dubowitz Syndrome
  • Dubowitz'S Syndrome

  • Dwarfism-Eczema-Peculiar Facies Syndrome

  • Intrauterine Growth Restriction, Short Stature, Microcephaly, Mild Intellectual Disability With Behavior Problems, Eczema, And Unusual And Distinctive Faci

Hypermethioninemia
  • Hepatic Methionine Adenosyltransferase Deficiency

  • Deficiency Of Methionine Adenosyltransferase

  • Glycine N-Methyltransferase Deficiency

  • Met

  • S-Adenosylhomocysteine Hydrolase Deficiency

  • Gnmt Deficiency

  • Mat Deficiency

  • Methionine Adenosyltransferase Deficiency

  • Methioninemia

  • Deficiency Of Acetyl-Coa Acetyltransferase

Wilms Tumor 1
  • Nephroblastoma

  • Wilms Tumor

  • WT1

  • Wilms' Tumor

  • Bilateral Wilms Tumor

  • Wilms Tumor, Type 1

  • Wilms Tumor, Somatic

  • Adult Nephroblastoma

  • Wt1 Disorder

  • Renal Embryonic Tumor

  • Adult Kidney Wilms Tumor

  • Childhood Kidney Wilms Tumor

  • Nonanaplastic Kidney Wilms Tumor

Williams-Beuren Syndrome
  • Williams Syndrome

  • WBS

  • Wms

  • Deletion 7q11.23

  • Monosomy 7q11.23

  • Chromosome 7q11.23 Deletion Syndrome, 1.5- To 1.8-Mb

  • Fanconi Schlesinger Syndrome

  • Beuren Syndrome

  • Elfin Facies Syndrome

  • Elfin Facies With Hypercalcemia

  • Hypercalcemia-Supravalvar Aortic Stenosis

  • Ws

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus RNMT MGD MGI:1915147
Bos taurus RNMT VGNC VGNC:34077
Felis catus RNMT VGNC VGNC:64710
Rattus norvegicus RNMT RGD RGD:1309242
Macaca mulatta RNMT VGNC VGNC:76710
Others RNMT NCBI