2. Metabolic Enzyme/Protease
  3. Amine N-methyltransferase
  4. LL320

LL320 is a selective NNMT inhibitor with a Ki,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH5, and SAHH.

For research use only. We do not sell to patients.

LL320

LL320 Chemical Structure

CAS No. : 2672496-32-9

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LL320 Related Antibodies

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PNMT NNMT

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Description

LL320 is a selective NNMT inhibitor with a Ki,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH5, and SAHH[1].

IC50 & Target

NNMT[1]
Molecular Weight

524.53

Formula

C24H28N8O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O[C@@H]1[C@H](O)[C@@H](CN(CC#CC2=CC=CC(C(N)=O)=C2)CC[C@H](N)C(O)=O)O[C@H]1N3C(N=CN=C4N)=C4N=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (190.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9065 mL 9.5323 mL 19.0647 mL
5 mM 0.3813 mL 1.9065 mL 3.8129 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.9065 mL 9.5323 mL 19.0647 mL 47.6617 mL
5 mM 0.3813 mL 1.9065 mL 3.8129 mL 9.5323 mL
10 mM 0.1906 mL 0.9532 mL 1.9065 mL 4.7662 mL
15 mM 0.1271 mL 0.6355 mL 1.2710 mL 3.1774 mL
20 mM 0.0953 mL 0.4766 mL 0.9532 mL 2.3831 mL
25 mM 0.0763 mL 0.3813 mL 0.7626 mL 1.9065 mL
30 mM 0.0635 mL 0.3177 mL 0.6355 mL 1.5887 mL
40 mM 0.0477 mL 0.2383 mL 0.4766 mL 1.1915 mL
50 mM 0.0381 mL 0.1906 mL 0.3813 mL 0.9532 mL
60 mM 0.0318 mL 0.1589 mL 0.3177 mL 0.7944 mL
80 mM 0.0238 mL 0.1192 mL 0.2383 mL 0.5958 mL
100 mM 0.0191 mL 0.0953 mL 0.1906 mL 0.4766 mL
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LL320 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LL3202672496-32-9LL 320LL-320Amine N-methyltransferaseNNMT inhibitorRNMTDPHSAHHInhibitorinhibitorinhibit

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