PLEKHA3 - pleckstrin homology domain containing A3 Gene

Homo sapiens

Also known as FAPP1

Gene ID: 65977 | Gene type: protein coding

About PLEKHA3

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,480,457-178,516,463 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 2.6), adrenal (RPKM 2.0) and 25 other tissues.

Summary

Enables identical protein binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHA3 Products(1)

mRNA	Protein	Name
NM_019091.4	NP_061964.3	pleckstrin homology domain-containing family A member 3

PLEKHA3 Protein Structure

0
100
200
300 a.a.

Protein Preferred Names

Protein Names

pleckstrin homology domain-containing family A member 3

FAPP-1

Related Diseases

Diseases

Alias

Rhizomelic Chondrodysplasia Punctata, Type 3

Rhizomelic Chondrodysplasia Punctata Type 3	RCDP3
Alkyldihydroxyacetonephosphate Synthase Deficiency	Alkylglycerone-Phosphate Synthase Deficiency
Agps Deficiency	Rhizomelic Chondrodysplasia Punctata 3
Chondrodysplasia Punctata, Rhizomelic, Type 3

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10680	PLEKHA3 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PLEKHA3	RGD	RGD:1305244
Mus musculus	PLEKHA3	MGD	MGI:1932515
Canis familiaris	PLEKHA3	VGNC	VGNC:53102
Macaca mulatta	PLEKHA3	VGNC	VGNC:81505
Felis catus	PLEKHA3	VGNC	VGNC:80308
Bos taurus	PLEKHA3	VGNC	VGNC:33005

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