PLEKHA3 - pleckstrin homology domain containing A3 Gene

Also Known as FAPP1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 65977

About PLEKHA3

Cytogenetic location: 2q31.2 Genomic coordinates (GRCh38): 2:178,480,457-178,516,463 (from NCBI)

This gene has 4 transcripts (splice variants), 221 orthologues and 5 paralogues. Ubiquitous expression in testis (RPKM 2.6), adrenal (RPKM 2.0) and 25 other tissues.

Summary

Enables identical protein binding activity and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in ceramide transport and intermembrane lipid transfer. Located in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]

PLEKHA3 Products (1)

mRNA Protein Name
NM_019091.4 NP_061964.3 pleckstrin homology domain-containing family A member 3

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
enables phosphatidylinositol-4-phosphate binding IDA
IDA: Inferred from direct assay
11001876 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
30659099 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLEKHA3 Protein Structure

PH

PH: PH domain (1 - 89)

  • 0
  • 100
  • 200
  • 300 a.a.
Protein Preferred Names Protein Names

pleckstrin homology domain-containing family A member 3

  • FAPP-1

PLEKHA3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
PLEKHA3 Q9HB20 MORF4L1 Homo sapiens Q9UBU8-2
Validated Y2H
32296183
Intra
PLEKHA3 Q9HB20 PLEKHA3 Homo sapiens Q9HB20
Y2H Prey Pooling
32296183
Intra
PLEKHA3 Q9HB20 PLEKHA3 Homo sapiens Q9HB20
Validated Y2H
32296183
Intra
PLEKHA3 Q9HB20 PLEKHA3 Homo sapiens Q9HB20
Y2H Array
32296183
Intra
PLEKHA3 Q9HB20 PLEKHA3 Homo sapiens Q9HB20
MAPPIT
32296183
Intra
PLEKHA3 Q9HB20 YWHAH Homo sapiens Q04917
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Rhizomelic Chondrodysplasia Punctata, Type 3

  • Rhizomelic Chondrodysplasia Punctata Type 3

  • RCDP3

  • Alkyldihydroxyacetonephosphate Synthase Deficiency

  • Alkylglycerone-Phosphate Synthase Deficiency

  • Agps Deficiency

  • Rhizomelic Chondrodysplasia Punctata 3

  • Chondrodysplasia Punctata, Rhizomelic, Type 3
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10680 PLEKHA3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PLEKHA3 RGD RGD:1305244
Mus musculus PLEKHA3 MGD MGI:1932515
Canis familiaris PLEKHA3 VGNC VGNC:53102
Macaca mulatta PLEKHA3 VGNC VGNC:81505
Felis catus PLEKHA3 VGNC VGNC:80308
Bos taurus PLEKHA3 VGNC VGNC:33005
Others PLEKHA3 NCBI