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Cat. No.: HY-186197

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RNMT-IN-1

RNMT-IN-1 is a RNMT inhibitor with a pIC₅₀ of 5.5. RNMT-IN-1 can be used for research on various cancers.

For research use only. We do not sell to patients.

CAS No.: 1381321-59-0
Formula: C₁₇H₁₈N₄OS
Molecular Weight:326.42

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

RNMT-IN-1 Chemical Structure

CAS No.: 1381321-59-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

RNMT-IN-1 is a RNMT inhibitor with a pIC₅₀ of 5.5. RNMT-IN-1 can be used for research on various cancers^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	Inhibition	33.64 % Compound: DDD01060606	Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 2uM Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 2uM	[PMID: 32078764]
HepG2	Inhibition	-6.8 % Compound: DDD01060606	Toxicity liver stage against HepG2, at 10uM Toxicity liver stage against HepG2, at 10uM	[PMID: 32078764]
HepG2	Inhibition	67.7 % Compound: DDD01060606	Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 10uM Screen against P. berghei liver stage (PbLuc), transformed with Luciferase, at 10uM	[PMID: 32078764]

In Vitro

RNMT-IN-1 inhibits purified RNMT with a pIC₅₀ of 5.5^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1381321-59-0
Molecular Weight 326.42
Formula C₁₇H₁₈N₄OS
SMILES

O=C(CC1=CSC=C1)N2CCCC(C2)C3=NNC4=C3C=CC=N4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. David Porter, et al. Inhibitors of rna methyltransferase. WO2026013291A1. WIPO (PCT). 2025-07-11.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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